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List of genes:
- C
- C15orf60
- C21orf99Alias:CTSP1
- CABYRAlias:CBP86, FSP-2, MGC9117
- CAGE1Alias:bA69L16.7, CTAG3, FLJ40441
- CALR3Alias:CRT2, FLJ25355, MGC26577
- CASC5Alias:AF15Q14, D40, KIAA1570
- CCDC110Alias:KM-HN-1, KMHN1, MGC33607
- CCDC33Alias:FLJ23168, FLJ32855, MGC34145
- CCDC36Alias:FLJ25320
- CCDC62
- CCDC83
- CDCA1
- CEP290Alias:3H11Ag, FLJ13615, FLJ21979, JBTS5, JBTS6, KIAA0373, LCA10, MKS4, NPHP6, rd16, SLSN6
- CEP55
- COX6B2Alias:COXVIB2, MGC119094
- CPXCR1
- CRISP2Alias:CRISP-2, GAPDL5, MGC111136, TPX1, TSP1
- CSAG1Alias:CSAGE
- CSAG2Alias:MGC149851, MGC149852, TRAG3
- CSAG3BAlias:CSAG2
- CT16.2
- CT45A1
- CT45A2Alias:CT45A2
- CT45A3Alias:CT45A3, RP13-36C9.1
- CT45A4
- CT45A5Alias:CT45A5
- CT45A6
- CT47A1Alias:CT47.1
- CT47A10Alias:CT47.10
- CT47A11Alias:CT47.11
- CT47A2Alias:CT47.2
- CT47A3Alias:CT47.3
- CT47A4Alias:CT47.4
- CT47A5Alias:CT47.5
- CT47A6Alias:CT47.6
- CT47A7
- CT47A8
- CT47A9Alias:CT47.9
- CT47B1
- CT66
AA884595 - CT69
BC040308 - CT70
BI818097 - CTAG1AAlias:ESO1, LAGE2A
- CTAG1BAlias:CTAG, CTAG1, ESO1, LAGE-2, LAGE2B, NY-ESO-1
- CTAG2Alias:ESO2, LAGE-1, LAGE-2b, MGC138724, MGC3803
- CTAGE-2
- CTAGE1Alias:CTAGE-1, CTAGE-2
- CTAGE5Alias:MEA6, MGEA, MGEA11, MGEA6
- CTCFLAlias:BORIS, CTCF-T, dJ579F20.2, MGC163358
- CTNNA2
- CXorf48Alias:FLJ20527, RP13-565O16.1
- Cxorf61Alias:FLJ20611, FLJ22913, KK-LC-1, RP3-452H17.2
- cyclin A1
- G
- GAGE1Alias:MGC33825
- GAGE12B
- GAGE12C
- GAGE12DAlias:MGC163246
- GAGE12E
- GAGE12F
- GAGE12GAlias:MGC132611, RP11-959H17.6
- GAGE12HAlias:RP11-959H17.7
- GAGE12IAlias:AL4, CT4.7, GAGE7B
- GAGE12JAlias:GAGE11
- GAGE13Alias:GAGE12A
- GAGE2AAlias:CT4.2, GAGE2, MGC120097, MGC96883, MGC96930, MGC96942
- GAGE3
- GAGE4Alias:GAGE5
- GAGE5
- GAGE6
- GAGE7Alias:GAGE-7
- GAGE8
- GOLGAGL2 FA
- GPAT2
- GPATCH2
- M
- MAEL
- MAGEA1Alias:MAGE1, MGC9326
- MAGEA10Alias:MAGE10, MGC10599
- MAGEA11Alias:MAGE-11, MAGE11, MAGEA-11, MGC10511
- MAGEA12Alias:MAGE12
- MAGEA2Alias:MAGE2, MAGEA2A, MGC131923
- MAGEA2BAlias:MAGE2, MAGEA2, MGC16973
- MAGEA3Alias:HIP8, HYPD, MAGE3, MGC14613
- MAGEA4Alias:MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MGC21336
- MAGEA5Alias:MAGE5, MGC129526
- MAGEA6Alias:MAGE-3b, MAGE3B, MAGE6, MGC52297
- MAGEA8Alias:MAGE8, MGC2182
- MAGEA9Alias:MAGE9, MGC8421
- MAGEA9B
LOC728269 - MAGEB1Alias:DAM10, MAGE-Xp, MAGEL1, MGC9322
- MAGEB2Alias:DAM6, MAGE-XP-2, MGC26438
- MAGEB3
- MAGEB4Alias:MGC33144
- MAGEB5Alias:MAGE-B5
- MAGEB6Alias:FLJ40242, MAGE-B6, MAGEB6A
- MAGEC1Alias:CT7, MAGE-C1, MGC39366
- MAGEC2Alias:CT10, HCA587, MGC13377
- MAGEC3Alias:HCA2, MAGE-C3, MAGEC4, MGC119270, MGC119271
- MCAK
- MMA1b
- MORC1Alias:MORC, ZCW6
- MPHOSPH1Alias:DKFZp434B0435, DKFZp434P0810, KRMP1, MPP-1, MPP1
- P
- PAGE1Alias:GAGE-9, GAGEB1, PAGE-1
- PAGE2Alias:GAGEC2, GAGEE2, MGC62094, PAGE-2
- PAGE2BAlias:GAGEE3
- PAGE3Alias:GAGED1, PAGE-3
- PAGE4Alias:FLJ35184, GAGEC1, JM27, PAGE-4
- PAGE5Alias:GAGEE1, PAGE-5
- PASD1
- PBKAlias:FLJ14385, Nori-3, SPK, TOPK
- PEPP2
- PIWIL2Alias:FLJ10351, HILI, MGC133049, mili, PIWIL1L
- PLAC1
- POTEA
- POTEB
- POTEC
- POTED
- POTEE
- POTEG
- POTEH
- PRAME
- PRM1
- PRM2Alias:FLJ27447
- PRSS54Alias:FLJ25339, Klkbl4
- PRSS55
- PTPN20A
- S
- SAGE1Alias:SAGE
- SEMG1
- SLCO6A1Alias:GST, MGC26949, OATP6A1, OATPY
- SPA17Alias:SP17, SP17-1
- SPACA3Alias:1700025M08Rik, ALLP17, LYC3, LYZL3, MGC119058, SLLP1
- SPAG1
- SPAG17
- SPAG4
- SPAG6
- SPAG8
- SPAG9Alias:FLJ13450, FLJ14006, FLJ26141, FLJ34602, HLC4, HSS, JLP, KIAA0516, MGC117291, MGC14967, MGC74461, PHET, PIG6
- SPANXA1Alias:NAP-X, SPAN-Xa, SPAN-Xb, SPANX, SPANX-A2, SPANXA2
- SPANXA2Alias:SPANX, SPANXA
- SPANXB1Alias:SPANX-B, SPANXB
- SPANXB2Alias:SPANX, SPANXB
- SPANXCAlias:CTp11, SPANX-C
- SPANXDAlias:dJ171K16.1, MGC119769, SPANX-D
- SPANXE
- SPANXN1Alias:SPANX-N1
- SPANXN2Alias:SPANX-N2
- SPANXN3Alias:SPANX-N3
- SPANXN4Alias:SPANX-N4
- SPANXN5Alias:SPANX-N5
- SPATA19
- SPEF2
- SPINLW1Alias:dJ461P17.2, EPPIN, EPPIN1, EPPIN2, EPPIN3, WAP7, WFDC7
- SPO11Alias:MGC39953
- SSX1Alias:MGC150425, MGC5162, SSRC
- SSX2Alias:HD21, HOM-MEL-40, MGC119055, MGC15364, MGC3884, SSX
- SSX2b
- SSX3Alias:MGC119054, MGC14495
- SSX4Alias:MGC119056, MGC12411
- SSX4B
- SSX5Alias:MGC9494
- SSX6Alias:dJ54B20.1
- SSX7
- SSX9
- SYCE1Alias:bA108K14.6, C10orf94, RP11-108K14.6
- SYCP1Alias:HOM-TES-14, MGC104417, SCP1
- T
- TAF7LAlias:dJ738A13.1, FLJ23157, TAF2Q
- TAG
- TDRD1Alias:FLJ21082
- TDRD4
- TDRD6Alias:bA446F17.4, DKFZp781I1148, FLJ43850, NY-CO-45, TDR2
- TEKT5
- TEX101
- TEX14
- TEX15Alias:DKFZP434M2415
- TFDP3Alias:CT30, E2F-like, HCA661, MGC161639
- THEGAlias:MGC26138
- TMEFF1
- TMEFF2
- TMEM108
- TMPRSS12
- TPPP2
- TPTEAlias:PTEN2
- TSGA10Alias:CEP4L
- TSP50
- TSPY1D
- TSPY1E
- TSPY1F
- TSPY1G
- TSPY1H
- TSPY1I
- TSPY2Alias:MGC103998, TSPYQ1
- TSPY3Alias:DYS14, pJA923, TSPY
- TSSK6Alias:FLJ24002, SSTK, TSSK4
- TTK
- TULP2Alias:TUBL2
Table 1.Tentative classification of CT antigens according to the expression pattern in human normal tissues
Show| Gene Symbol | Classification |
|---|---|
| ACRBP | testis-selective |
| ACTL8 | testis-selective |
| ADAM2 | testis-selective |
| ADAM29 | testis-selective |
| AKAP3 | testis-selective |
| AKAP4 | not available |
| ANKRD45 | not available |
| ARMC3 | testis-selective |
| ARX | not available |
| ATAD2 | not available |
| BAGE | testis-selective |
| BAGE2 | testis-selective |
| BAGE3 | testis-selective |
| BAGE4 | testis-selective |
| BAGE5 | testis-selective |
| BRDT | testis-selective |
| C15orf60 | not available |
| C21orf99 | testis-selective |
| CABYR | testis-selective |
| CAGE1 | not available |
| CALR3 | not available |
| CASC5 | testis-selective |
| CCDC110 | testis-selective |
| CCDC33 | testis-selective |
| CCDC36 | testis-selective |
| CCDC62 | not available |
| CCDC83 | not available |
| CDCA1 | not available |
| CEP290 | testis-selective |
| CEP55 | not available |
| COX6B2 | testis-selective |
| CPXCR1 | testis-restricted |
| CRISP2 | testis-selective |
| CSAG1 | not found in testis |
| CSAG2 | testis-restricted |
| CSAG3B | not available |
| CT16.2 | testis-restricted |
| CT45A1 | not available |
| CT45A2 | not available |
| CT45A3 | not available |
| CT45A4 | not available |
| CT45A5 | not available |
| CT45A6 | not available |
| CT47A1 | not available |
| CT47A10 | not available |
| CT47A11 | not available |
| CT47A2 | not available |
| CT47A3 | not available |
| CT47A4 | not available |
| CT47A5 | not available |
| CT47A6 | not available |
| CT47A7 | not available |
| CT47A8 | not available |
| CT47A9 | not available |
| CT47B1 | not available |
| CT66/AA884595 | testis-selective |
| CT69/BC040308 | testis-restricted |
| CT70/BI818097 | testis-restricted |
| CTAG1A | testis-restricted |
| CTAG1B | testis-selective |
| CTAG2 | testis-selective |
| CTAGE-2 | not available |
| CTAGE1 | testis/brain-restricted |
| CTAGE5 | testis-selective |
| CTCFL | testis-selective |
| CTNNA2 | testis/brain-restricted |
| CXorf48 | testis-restricted |
| Cxorf61 | testis-restricted |
| cyclin A1 | not available |
| DCAF12 | not available |
| DDX43 | testis-selective |
| DDX53 | testis-restricted |
| DKKL1 | testis-restricted |
| DMRT1 | not available |
| DNAJB8 | not available |
| DPPA2 | not available |
| DSCR8 | testis-selective |
| EDAG, NDR | not available |
| ELOVL4 | not available |
| FAM133A | testis/brain-restricted |
| FAM46D | not available |
| FATE1 | testis-selective |
| FBXO39 | not available |
| FMR1NB | testis-selective |
| FTHL17 | testis-restricted |
| GAGE1 | testis/brain-restricted |
| GAGE12B | not available |
| GAGE12C | not available |
| GAGE12D | not available |
| GAGE12E | not available |
| GAGE12F | not available |
| GAGE12G | not available |
| GAGE12H | not available |
| GAGE12I | not available |
| GAGE12J | not available |
| GAGE13 | not available |
| GAGE2A | testis/brain-restricted |
| GAGE3 | not available |
| GAGE4 | testis/brain-restricted |
| GAGE5 | testis/brain-restricted |
| GAGE6 | testis-restricted |
| GAGE7 | testis/brain-restricted |
| GAGE8 | testis/brain-restricted |
| GOLGAGL2 FA | not available |
| GPAT2 | not available |
| GPATCH2 | not available |
| HIWI, MIWI, PIWI | not available |
| HORMAD1 | testis/brain-restricted |
| HORMAD2 | not available |
| HSPB9 | testis-selective |
| IGSF11 | not available |
| IL13RA2 | not available |
| IMP-3 | not available |
| JARID1B | testis-selective |
| KIAA0100 | not available |
| LAGE-1b | not available |
| LDHC | testis-selective |
| LEMD1 | testis-selective |
| LIPI | testis-selective |
| LOC130576 | not available |
| LOC196993 | not available |
| LOC348120 | not available |
| LOC440934 | not available |
| LOC647107 | not available |
| LOC728137 | not available |
| LUZP4 | testis-selective |
| LY6K | not available |
| MAEL | not available |
| MAGEA1 | testis-restricted |
| MAGEA10 | testis-selective |
| MAGEA11 | testis-selective |
| MAGEA12 | testis-selective |
| MAGEA2 | testis-restricted |
| MAGEA2B | testis-restricted |
| MAGEA3 | testis-selective |
| MAGEA4 | testis-selective |
| MAGEA5 | testis-selective |
| MAGEA6 | testis-selective |
| MAGEA8 | testis-selective |
| MAGEA9 | testis/brain-restricted |
| MAGEA9B/LOC728269 | not available |
| MAGEB1 | testis-restricted |
| MAGEB2 | testis-restricted |
| MAGEB3 | testis-restricted |
| MAGEB4 | testis-restricted |
| MAGEB5 | testis-restricted |
| MAGEB6 | testis-restricted |
| MAGEC1 | testis-restricted |
| MAGEC2 | testis/brain-restricted |
| MAGEC3 | testis/brain-restricted |
| MCAK | not available |
| MMA1b | not available |
| MORC1 | testis-selective |
| MPHOSPH1 | testis-selective |
| NLRP4 | testis-selective |
| NOL4 | not available |
| NR6A1 | not available |
| NXF2 | testis-selective |
| NXF2B | not available |
| NY-ESO-1 | not available |
| ODF1 | not available |
| ODF2 | not available |
| ODF3 | not available |
| ODF4 | not available |
| OIP5 | testis-selective |
| OTOA | not available |
| PAGE1 | not found in testis |
| PAGE2 | testis-restricted |
| PAGE2B | testis-restricted |
| PAGE3 | testis/brain-restricted |
| PAGE4 | testis-selective |
| PAGE5 | testis-selective |
| PASD1 | testis/brain-restricted |
| PBK | testis-selective |
| PEPP2 | not available |
| PIWIL2 | testis-selective |
| PLAC1 | testis-selective |
| POTEA | not available |
| POTEB | not available |
| POTEC | not available |
| POTED | not available |
| POTEE | not available |
| POTEG | not available |
| POTEH | not available |
| PRAME | not available |
| PRM1 | not available |
| PRM2 | not available |
| PRSS54 | testis-selective |
| PRSS55 | not available |
| PTPN20A | not available |
| RBM46 | testis-selective |
| RGS22 | not available |
| ROPN1 | testis-selective |
| RQCD1 | not available |
| SAGE1 | testis-restricted |
| SEMG1 | not available |
| SLCO6A1 | testis-selective |
| SPA17 | testis-selective |
| SPACA3 | testis-selective |
| SPAG1 | not available |
| SPAG17 | not available |
| SPAG4 | not available |
| SPAG6 | not available |
| SPAG8 | not available |
| SPAG9 | testis-selective |
| SPANXA1 | testis-restricted |
| SPANXA2 | testis-restricted |
| SPANXB1 | testis-restricted |
| SPANXB2 | not available |
| SPANXC | testis-restricted |
| SPANXD | testis-restricted |
| SPANXE | testis-restricted |
| SPANXN1 | not available |
| SPANXN2 | not available |
| SPANXN3 | not available |
| SPANXN4 | not available |
| SPANXN5 | testis-restricted |
| SPATA19 | not available |
| SPEF2 | not available |
| SPINLW1 | testis-selective |
| SPO11 | testis-selective |
| SSX1 | testis-restricted |
| SSX2 | testis-restricted |
| SSX2b | not available |
| SSX3 | testis-restricted |
| SSX4 | testis-selective |
| SSX4B | not available |
| SSX5 | not found in testis |
| SSX6 | not found in testis |
| SSX7 | not found in testis |
| SSX9 | not found in testis |
| SYCE1 | testis-selective |
| SYCP1 | testis-selective |
| TAF7L | testis-selective |
| TAG | not available |
| TDRD1 | testis-selective |
| TDRD4 | not available |
| TDRD6 | testis-selective |
| TEKT5 | not available |
| TEX101 | not available |
| TEX14 | testis-restricted |
| TEX15 | testis-selective |
| TFDP3 | testis-selective |
| THEG | testis-selective |
| TMEFF1 | not available |
| TMEFF2 | not available |
| TMEM108 | not available |
| TMPRSS12 | not available |
| TPPP2 | not available |
| TPTE | testis-selective |
| TSGA10 | testis-selective |
| TSP50 | testis-selective |
| TSPY1D | not available |
| TSPY1E | not available |
| TSPY1F | not available |
| TSPY1G | not available |
| TSPY1H | not available |
| TSPY1I | not available |
| TSPY2 | not available |
| TSPY3 | testis-restricted |
| TSSK6 | testis-selective |
| TTK | not available |
| TULP2 | testis-selective |
| VENTXP1 | not available |
| XAGE-3b | not available |
| XAGE-4/RP11-167P23.2 | not available |
| XAGE1 | testis-selective |
| XAGE1B | not available |
| XAGE1C | not available |
| XAGE1D | not available |
| XAGE1E | not available |
| XAGE2 | testis-selective |
| XAGE2B/CTD-2267G17.3 | not available |
| XAGE3 | testis-selective |
| XAGE5 | testis-restricted |
| ZNF165 | testis-selective |
| ZNF645 | not available |
Table 2.Genes that were computationally predicted as CT antigen based on the expression pattern of digital data (5, REF)
Show| Gene Symbol |
|---|
| SPANXN1 |
| SSX5 |
| SSX6 |
| SSX7 |
| SSX9 |
Table 3.Gene symbols that are actually splicing variants
Show| Gene Symbol | Splicing variant of |
|---|---|
| CT16.2 | PAGE5 |
| CTAGE-2 | CTAGE1 |
| LAGE-1B | CTAG2 |
| MMA1b | DSCR8 |
| XAGE-3B | XAGE3 |
Table 4.Gene symbols that were unified because they align in the same region in the human genome
Show| Gene Symbol | Reason |
|---|---|
| BAGE2 | same as BAGE |
| BAGE3 | same as BAGE |
| BAGE4 | same as BAGE |
| BAGE5 | same as BAGE |
| CT47B1 | The cDNA evidence for this gene is DB458760, a 447 nt long intronless EST that aligns to one CT47 exon. This entry should not be considered a gene. RefSeqs as of October, 2007 |
| GAGE3 | The mRNA evidence for this gene (U19144) is a chimera that links two GAGE genes and was therefore not considered an independent gene. RefSeqs as of October, 2007 |
| SPANXE | SPANXE's mRNA aligns in the same locus of SPANXD with mismatches, and
therefore, they are the same gene. RefSeqs as of October, 2007 |
Table 5.CT genes present in multiple copies (total of 15) in the human genome. GAGE genes were annotated by Brian Stevenson from the Lausanne branch of the LICR.
Show| Gene Symbol | Copies |
|---|---|
| CSAG2 | CSAG3B |
| CT45A1 | CT45-6 RP13-36C9.6 CT45-4 RP13-36C9.3 RP13-36C9.1 |
| CT47A1 | RP6-166C19.11 RP6-166C19.10 RP6-166C19.9 CT47.8 CT47.7 RP6-166C19.6 RP6-166C19.5 RP6-166C19.4 RP6-166C19.3 RP6-166C19.2 |
| CTAG1B | CTAG1A |
| GAGE1 | GAGE12H GAGE12G GAGE12F GAGE12E GAGE12D GAGE12C GAGE12B GAGE13 GAGE12J GAGE8 GAGE12I GAGE7 GAGE6 GAGE5 GAGE4 GAGE2A |
| MAGEA2 | MAGEA2B |
| MAGEA9 | LOC728269 |
| NXF2 | NXF2B |
| SPANXA1 | SPANXA2 |
| SPANXB1 | SPANXB2 |
| SSX2 | SSX2b |
| SSX4 | SSX4B |
| TSPY3 | TSPY1I TSPY1H TSPY1G TSPY1F TSPY1E TSPY1D LOC728137 TSPY2 |
| XAGE1 | XAGE1E XAGE1D XAGE1C XAGE1B |
| XAGE2 | CTD-2267G17.3 |
Table 6.Groups of genes with > 40% ID among them
Show| Group | Genes |
|---|---|
| G1 | CSAG3B, CSAG1, CSAG2 |
| G2 | RP13-36C9.6, CT45-6, CT45-4, RP13-36C9.3, RP13-36C9.1, CT45-1 |
| G3 | RP6-166C19.4, RP6-166C19.1, RP6-166C19.2, RP6-166C19.3, CT47.8, RP6-166C19.11, RP6-166C19.5, RP6-166C19.6, CT47.7, RP6-166C19.10, RP6-166C19.9 |
| G4 | CTAG1A, CTAG2, CTAG1B, CTAG1B, CTAG1A, CTAG2 |
| G5 | CTAGE1, CTAGE5 |
| G6 | GAGE13, GAGE11, GAGE8, GAGE7B, GAGE6, GAGE7, GAGE5, GAGE4, GAGE1, GAGE2, GAGE12C, GAGE12D, PAGE5, XAGE5, RP11-167P23.2, XAGE3, CTD-2267G17.3, XAGE2, GAGE12H, GAGE12G, GAGE12B, PAGE1, PAGE4, PAGE3, PAGE2B, GAGE12F, GAGE12E, PAGE2 |
| G7 | XAGE1B, XAGE1E, XAGE1D, XAGE1, XAGE1C |
| G8 | MAGEB1, MAGEA9, MAGEA9B, MAGEA11, MAGEA12, MAGEA10, MAGEB2, MAGEC3, MAGEC2, MAGEC1, MAGEB6, MAGEB3, MAGEA8, MAGEA6, MAGEA1, MAGEA2, MAGEB5, MAGEA3, MAGEA4, MAGEA5, MAGEA2B, MAGEB4 |
| G9 | NXF3, NXF2B, NXF2, NXF5 |
| G10 | SPANXA2, SPANXN3, SPANXN5, SPANXN4, SPANXN2, SPANXN1, SPANXD, SPANXC, SPANXB2, SPANXB1, SPANXA1 |
| G11 | SSX5, SSX4B, SSX7, SSX4, SSX2, SSX1, SSX2b, SSX9, SSX3, SSX6 |
| G12 | TSPY2, LOC728137 |
*XAGE1 does not present detectable similarity with the XAGE/GAGE/PAGE family. Also see http://www.treefam.org/. However, the presence of a GAGE domain may indicate that they belong to the family.
Table 7.Bibliographical references
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