Summary
Gene:
GAGE12D (official gene symbol)Other symbol:
GAGE12DCT family:
CT4CT identifier:
Aliases from NCBI:
MGC163246Unified entry for genes GAGE1, GAGE12B, GAGE12C, GAGE12D, GAGE12E, GAGE12F, GAGE12G, GAGE12H, GAGE12I, GAGE12J, GAGE13, GAGE2A, GAGE4, GAGE5, GAGE6, GAGE7, GAGE8 (nearly-identical copies)
The CTpedia entry for GAGE refers to a unified entry for GAGE1, GAGE11, GAGE12B-J GAGE13, GAGE2A, GAGE4, GAGE4, GAGE6, GAGE7, GAGE7b and GAGE8 which are nearly identical gene copies.
LICR validation studies in normal tissues show that GAGE mRNA is very highly expressed and restricted to testis.
GAGE has been reported to be expressed in hematologic, brain, hepatobiliary, lung, melanocytic, ovarian, and testicular cancers at the mRNA level. GAGE has been reported to be expressed in lung and melanocytic cancers at the protein level.
Spontaneous humoral and cellular responses against GAGE have been detected in cancer patients. There are no reports of immunization with GAGE.
The function of GAGE is unknown.