MAGEC2 is located at Xq27.

MAGEC2 has been reported to be expressed in hematologic, hepatobiliary, and lung cancers at the mRNA level. MAGEC2 has been reported to be expressed in normal testis and cerebellum, and in hepatobiliary cancers at the protein level.

Spontaneous humoral and cellular responses against MAGEC2 have been detected in cancer patients

MAGE family proteins bind to and activate RING E3 ubiquitin ligases. MAGEC2 promotes the activity of theTRIM28 E3 RING protein and p53 degradation.