TDFP3 is located at Xq26.2.

TFDP3 has been reported to be expressed in hepatobiliary cancers at the mRNA level.

Spontaneous humoral, but not cellular, immune responses against TFDP3 have been detected in cancer patients.

TFDP3 binds to the E2F proteins and functions as a negative regulator of E2F-mediated transcriptional activation, which impairs cell cycle progression from G1 to S phase.