Immune response
Gene:
MAGEA12 (official gene symbol)Other symbol:
MAGEA12CT family:
CT1CT identifier:
CT1.12Aliases from NCBI:
MAGE12Humoral immune response
Spontaneous humoral immune reponses against MAGEA12 have been detected in cancer patients.
Cellular immune response
Akiyama et al., 2012 (PMID:22707303) observed CTL-inducing activity of MAGE-A12 HLA-A24-binding peptides in melanoma patients.
The following MAGEA12 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
| HLA | HLA Frequency (%) | Peptide | Position | Lymphocyte Stimulation Method |
PMID |
|---|---|---|---|---|---|
| A2 | 44 | FLWGPRALV | 271-279 | peptide | 7805731 |
| Cw7 | 41 | VRIGHLYIL | 170-178 | autologous tumor cells | 10820289 |
| Cw7 | 41 | EGDCAPEEK | 212-220 | lentivirus-dendritic cells | 14764691 |
| DP4 | 75 | REPFTKAEMLGSVIR | 127-141 | peptide | 16988823 |
| DR13 | 19 | AELVHFLLLKYRAR | 114-127 | protein | 10049940 |
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with MAGEA12.