Immune response
Gene:
LY6K (official gene symbol)Other symbol:
LY6KCT family:
CT97CT identifier:
CT97Humoral immune response
Spontaneous humoral immune responses against LY6K have been detected in cancer patients.
Tumor type
Tumor stage
Frequency
Antibody detection methodology
PMID
Non small cell lung carcinoma 38/112 (34%) ELISA 18089789 Squamous cell carcinoma 26/81 (32%) ELISA 18089789
Cellular immune response
LY6K protein is recognized by CTLs and LY6K-177 HLA-A24-restricted epitope can induce potent and specific immune responses against lung and esophageal cancer cells (Suda et al., 2007 PMID: 17784873).Specific T-cell responses to epitope peptides derived from LY6K are induced in TIL, RLNL, and PBL from HLA-A2402 patients with esophageal squamous cell carcinoma Mizukami et al., 2008 PMID: 18452554).