Immune response
Gene:
SPANXB1 (official gene symbol)Other symbol:
SPANXB1CT family:
CT11CT identifier:
CT11.2Aliases from NCBI:
SPANX-B , SPANXBUnified entry for genes SPANXB1, SPANXB2 (nearly-identical copies)
Humoral immune response
Antibodies against SPAN-X were detected in sera of cancer patients by Western blot (Westbrook et al., 2000).
Cellular immune response
SPAN-XB-derived peptides can elicit a consistent CD8 T cell response in healthy donors and patients with multiple myeloma (Frank et al., 2008 PMID: 18398747).
“In vitro” immunizations with SPANX-B-treated dendritic cells generate both helper CD4+ T and cytolytic CD8+ T cells. SPANX-B-specific CD8+ T cells generated from normal human peripheral blood lymphocytes can recognize and efficiently kill the HLA-matched human primary melanomas (Almanzar et al., 2009 PMID: 19276289).
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with SPANXB1.