Protein
Gene:
SYCE1 (official gene symbol)Other symbol:
SYCE1CT family:
CT76CT identifier:
CT76Aliases from NCBI:
bA108K14.6 , C10orf94 , RP11-108K14.6RefSeq :
Protein Names (UNIPROT)
Synaptonemal complex central element protein 1
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| central element of the synaptonemal complex (by similarity) | spermatocytes | Immunofluorescence | 15944401 |
Protein function and interaction
In mouse, SYCE1 interacts with the transverse filament protein SYCP1, and its localisation to the central element of the synaptonemal complex appears to depend on recruitment by SYCP1. Pull-down and immunoprecipitation assays demonstrated that SYCE1 interacts with SYCE2 (CESC1) and with SYCP1 (CT8). This suggests a role for SYCE1 and SYCE2 in synaptonemal-complex assembly, and perhaps also stability and recombination. SYCE1 and SYCE2 could be primarily involved in assembling the synaptonemal-complex as a robust structure that endures the mechanical stress but is also sufficiently flexible to twist at the sites of recombination (Costa et al, 2005 PMID: 15944401, by similarity). Hamet et al, 2006 (PMID: 16968740) have shown that SYCE1 interacts with a complex formed by SYCE2 and TEX12 (testis expressed sequence 12). SYCE1 interacts more directly with SYCP1 and could thus anchor the central element proteins to the transverse filaments (by similarity).
Domain analysis
