Protein
Gene:
CCDC110 (official gene symbol)Other symbol:
CCDC110CT family:
CT52CT identifier:
CT52Aliases from NCBI:
KM-HN-1 , KMHN1 , MGC33607RefSeq :
Protein Names (UNIPROT)
Coiled-coil domain-containing protein 110
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| nucleus and centrosome | AU-2OS (osteosarcoma cell line) | Immunofluorescence | 18160854 |
| nucleus (interphase) and chromosomes (mitosis) | TE13 (esophageal cancer cell line) | Immunofluorescence | 15447989 |
Protein function and interaction
KM-HN-1 is a member of centrosome localizing proteins.The C-terminal coiled-coil region contains the “structure maintenance of chromatin” (SMC) motif and the leucine zipper motif, which are important for proper centrosomal localization. Colocalization of KMHN-1 and hCdc14A protein, known to localize to the centrosome and to perform crucial functions in centrosome duplication and mitosis was observed (Park et al., 2007 PMID: 18160854).
Studies with the yeast two-hybrid system revealed interaction of the KM-HN-1 protein with the high-risk human papillomavirus type 18 E6 oncogene (Li et al., 2008 PMID: 18278468).
Domain analysis
| COG1196 |  | Smc |
