Protein
Gene:
MAGEA11 (official gene symbol)Other symbol:
MAGEA11CT family:
CT1CT identifier:
CT1.11Aliases from NCBI:
MAGE-11 , MAGE11 , MAGEA-11 , MGC10511RefSeq :
Protein Names (UNIPROT)
Melanoma-associated antigen 11
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasm and nucleus | COS | Immunofluorescence | 15684378 |
| nucleus | endometrial glandular epithelium | IHC | 18048459 |
| cytoplasm and nucleus | foreskin fibroblasts | Immunofluorescence | 15684378 |
| nucleus | Hela cells | IHC | 9495246 |
| cytoplasm and nucleus | prostate cancer cell lines | Immunofluorescence | 15684378 |
Protein function and interaction
MAGEA11 interacts with the androgen receptor (AR). It functions as a AR coregulator that increases AR activity by modulating the AR interdomain interaction (Bai et al., 2005).
Bai et al., 2007 demonstrated that it increases AR transcriptional activity during the establishment of uterine receptivity in the human female.
A yeast two-hybrid screen, pull-down assays and coimmunoprecipitation experiments showed the interaction between MAGE A11 and the hypoxia-inducible factor prolyl hydroxylase 2 (PHD). MAGEA11 inhibits PHD2 and activates hypoxic responses (Aprelikova et al., 2009 PMID: 19147576).
MAGE family proteins may enhance ubiquitin ligase activity through recruitment and/or stabilization of the E2 ubiquitin conjugating enzymes at the E3-substrate complex (Doyle et al, 2010 PMID: 20864041).
