Protein
Gene:
PRM1 (official gene symbol)Other symbol:
PRM1CT family:
CT94CT identifier:
CT94.1RefSeq :
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| nucleus | sperm | Immunofluorescent and fluorescence in situ hybridi | 18478156 |
| nucleus | spermatids | Immunoelectron microscopy | 8466000 |
Protein function and interaction
Protamines are the most abundant DNA-binding proteins in the nucleus of sperm. Protamines have a role in the condensation of the genome and in the inhibition of transcriptional activity during spermatogenesis (Balhorn, 1982 PMID: 7096440). Prm1 was isolated as a partner of SEMG1 in yeast two-hybrid experiments (Meklat et al. 2009 PMID: 19036087).