Protein

Gene:

SSX1 (official gene symbol)

Other symbol:

SSX1

CT family:

CT5

CT identifier:

CT5.1

Aliases from NCBI:

MGC150425 , MGC5162 , SSRC

RefSeq :

NP_005626.1

Protein Names (UNIPROT)

Protein SSX1

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
associated chromatin during mitosis	COS7 cell lines	Immunofluorescence	10348348
nucleus	COS7 cell lines	Immunofluorescence	10348348
nucleus and cytoplasm	Mesenchymal Stem Cells	Immunofluorescence	15781633
colocalized with the RING1 and BMI-1 polycomb-group nuclear bodies components	synovial sarcoma cell line 2C4	Immunofluorescence	10348348

Protein function and interaction

SSX1 may be fused to the SYT gene as a result of the t(X;18) translocation in synovial sarcoma (Clark et al., 1994).

SSX proteins appear to be transcriptional regulators, whose actions are mediated primarily through association with or recruitment of Polycomb group repressors by the SSX-RD domain, mapped to the C-terminal of SSX proteins (Ladanyi, 2001 PMID: 11607825). LIM homeobox protein LHX4 was identified among the proteins that interact with the SSX C-terminal repression domain (de Bruijn et al., 2008 PMID: 17667940).