CTDatabase

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List of genes:

B
- BAGEAlias:BAGE1
- BAGE2
- BAGE3
- BAGE4
- BAGE5
- BRDTAlias:BRD6

E
- EDAG, NDR
- ELOVL4

I
- IGSF11
- IL13RA2
- IMP-3

J
- JARID1BAlias:FLJ10538, FLJ12459, FLJ12491, FLJ16281, FLJ23670, KDM5B, PLU-1, PUT1, RBBP2H1A

K
- KIAA0100

V
- VENTXP1Alias:NA88A, VENTX2P1

Z
- ZNF165Alias:LD65, ZSCAN7
- ZNF645

Protein

Gene:

KIF2C (official gene symbol)

Other symbol:

MCAK

CT family:

CT139

CT identifier:

CT139

RefSeq :

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
Nucleous and nuclear membrane	Colon cancer cell line	Immunofluorescence	19937794
centromere and kinetochore	HeLa cervical cancer cell line	Immunofluorescence	14960279

Protein function and interaction

KIF2C (MCAK) is an ATP-dependent microtubule depolymerase which regulates the turnover of microtubules at the kinetochore and acts in chromosome segregation during mitosis. AuroraB complex is a critical regulator of MCAK function (Andrews et al., 2004 PMID: 14960279). MCAK is essential for genome stability ensured by temporal control of kinetochore-microtubule dynamics and for the correction of segregation defects (Bakhoum et al., 2009 PMID: 19060894). MCAK activity is regulated by polo-like kinase1 (PLK1) phosphorylation (Zhang et al., 2011 PMID: 21078677).