Protein
Gene:
CCNA1 (official gene symbol)Other symbol:
cyclin A1CT family:
CT146CT identifier:
CT146RefSeq :
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasmic and nucleous | embryonal carcinoma | IHC | 14696091 |
| nucleus | spermatocyte | IHC | 14696091 |
| cytoplasm | teratoma, yolk sac carcinoma and choriocarcinoma | IHC | 14696091 |
Protein function and interaction
The cyclin family members and their partners, the CDK kinases, control of the cell cycle. Cyclin A1 plays an essential role in male gametogenesis, acting at G1/S and G2/M transitions. Cyclin A1 associates with CDK2 (Yang et al.,1997 PMID: 9041194) and the complex phosphorylates the Rb family of proteins and E2F-1 (Yang et al., 1999 PMID: 10022926). Cyclin A1 contributes to G1/S cell cycle progression in somatic cells, as well (Ji et al., 2005 PMID:15829981).