1 |
07/01/2004 |
15220211 |
Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q. |
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To ascertain whether distinct chromosomal loci existed that were linked to severe obesity, as well as to utilize the increased heritability of this excessive phenotype, we performed a genome-wide scan...
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2 |
01/01/2004 |
14708010 |
Tubby proteins: the plot thickens. |
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The tubby mouse, which shows late-onset obesity and neurosensory deficits, arises from a mutation in the Tub gene. Tub shares homology with the genes for tubby-like proteins Tulp1, Tulp2 and Tulp3. Ab...
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3 |
07/25/2001 |
11483369 |
Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene. |
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The tubby-like protein 1 (tulp1) gene is a member of the tubby multigene family which includes tub, tulp1, tulp2 and tulp3. Human and mouse tulp1 genes were cloned and mutations in tulp1 have been imp...
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4 |
09/30/2000 |
11000483 |
GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. |
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The tubby gene family consists of four members, TUB, TULP1, TULP2 and TULP3, with unknown function. However, a splice junction mutation within the mouse tub gene leads to retinal and cochlear degenera...
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5 |
12/01/1998 |
9828123 |
Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. |
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Tubby and related proteins are derived from a small family of novel genes. The carboxytermini of this family are highly conserved across a number of species including humans, mice, Caenorhabditis eleg...
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6 |
04/01/1997 |
9096357 |
Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. |
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Tubby, an autosomal recessive mutation, mapping to mouse chromosome 7, was recently found to be the result of a splicing defect in a novel gene with unknown function. Database searches revealed that s...
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