1 |
12/05/2007 |
18053092 |
Cancer stem cells: the lessons from precancerous stem cells. |
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How a cancer is initiated and established remains elusive despite all the advances in decades of cancer research. Recently the cancer stem cell (CSC) hypothesis has been revived, challenging the long-...
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2 |
05/04/2007 |
17446352 |
Developmentally regulated piRNA clusters implicate MILI in transposon control. |
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Nearly half of the mammalian genome is composed of repeated sequences. In Drosophila, Piwi proteins exert control over transposons. However, mammalian Piwi proteins, MIWI and MILI, partner with Piwi-i...
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3 |
04/01/2007 |
17431699 |
Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. |
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In order to identify novel genes involved in early meiosis and early ovarian development in the mouse, we used microarray technology to compare transcriptional activity in ovaries without meiotic germ...
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4 |
01/01/2007 |
17566262 |
Putative human male germ cells from bone marrow stem cells. |
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Germ cells must develop along distinct male or female paths to produce the spermatozoa or oocyte required for sexual reproduction. Male germline stem cells maintain spermatogenesis in the postnatal hu...
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5 |
01/01/2007 |
17356702 |
Precancerous stem cells have the potential for both benign and malignant differentiation. |
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Cancer stem cells (CSCs) have been identified in hematopoietic and solid tumors. However, their precursors-namely, precancerous stem cells (pCSCs) -have not been characterized. Here we experimentally ...
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6 |
08/01/2006 |
16787967 |
Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway? |
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Meiotic silencing of unsynapsed chromatin (MSUC) is a key mechanism in spermatogenesis and a model system to study the dynamics of gene silencing. Here we show that MAEL, the ortholog of Drosophila's ...
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7 |
07/13/2006 |
16751777 |
A novel class of small RNAs bind to MILI protein in mouse testes. |
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Small RNAs bound to Argonaute proteins recognize partially or fully complementary nucleic acid targets in diverse gene-silencing processes. A subgroup of the Argonaute proteins--known as the 'Piwi fam...
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8 |
07/01/2006 |
16652109 |
Derivation of male germ cells from bone marrow stem cells. |
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Recent studies have demonstrated that somatic stem cells have a more flexible potential than expected, whether put into tissue or cultured under different conditions. Bone marrow (BM)-derived stem cel...
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9 |
02/01/2006 |
16261612 |
Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes. |
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The piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Arabidopsis to hum...
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10 |
01/15/2006 |
16377660 |
Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. |
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The genes of the piwi family are defined by conserved PAZ and Piwi domains and play important roles in stem-cell self-renewal, RNA silencing and translational regulation in various organisms. Both, mo...
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11 |
08/01/2004 |
15280553 |
In vivo and in vitro differentiation of male germ cells in the mouse. |
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Primordial germ cells appear in the embryo at about day 7 after coitum. They proliferate and migrate towards the genital ridge. Once there, they undergo differentiation into germ stem cells, known as ...
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12 |
02/01/2004 |
14736746 |
Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. |
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The piwi family genes, which are defined by conserved PAZ and Piwi domains, play important roles in stem cell self-renewal, RNA silencing, and translational regulation in various organisms. To reveal ...
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13 |
09/01/2003 |
12906857 |
Identification of eight members of the Argonaute family in the human genome small star, filled. |
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A number of genes have been identified as members of the Argonaute family in various nonhuman organisms and these genes are considered to play important roles in the development and maintenance of ger...
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14 |
11/01/2002 |
12489526 |
Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8. |
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Retinoids are known to be required for vertebrate reproduction, and in the male, for the maintenance of normal testicular structure and function. Previously several novel retinoic acid responsive gene...
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15 |
10/01/2001 |
11578866 |
Two mouse piwi-related genes: miwi and mili. |
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Genes belonging to the piwi family are required for stem cell self-renewal in diverse organisms. We cloned mouse homologues of piwi by RT-PCR using degenerative primers. The deduced amino acid sequenc...
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