Immune response
Gene:
MAGEA2 (official gene symbol)Other symbol:
MAGEA2CT family:
CT1CT identifier:
CT1.2Aliases from NCBI:
MAGE2 , MAGEA2A , MGC131923Unified entry for genes MAGEA2, MAGEA2B (nearly-identical copies)
Humoral immune response
There are no published reports of spontaneous humoral immune responses against MAGEA2 in cancer patients.
Cellular immune response
Goodyear et al., 2008 PMID: 18658027) and the following MAGEA2 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
HLA
HLA Frequency (%)
Peptide
Position
Lymphocyte
Stimulation
Method PMID
A2 44 YLQLVFGIEV 157-166 peptide 9544234 A24 20 EYLQLVFGI 156-164 peptide 10473111 B37 3 REPVTKAEML 127-136 autologous tumor cells 10363990 Cw7 41 EGDCAPEEK 212-220 lentivirus-dendritic cells 14764691 DR13 19 LLKYRAREPVTKAE 121-134 protein 10049940
Induced immune response
Studies that demonstrated induction of immune responses in patients immunized with MAGEA2.
| Immunogen | PMID |
|---|---|
| Dendritic cells pulsed with multiple peptides including MAGEA2 |