Immune response
Gene:
MAGEA6 (official gene symbol)Other symbol:
MAGEA6CT family:
CT1CT identifier:
CT1.6Aliases from NCBI:
MAGE-3b , MAGE3B , MAGE6 , MGC52297Humoral immune response
Spontaneous humoral immune responses against MAGEA6 have been detected in cancer patients.
Cellular immune response
Spontaneous cellular immune responses against MAGEA6 have been detected by Zorn et al., 1999. Akiyama et al., 2012 (PMID:22707303) observed CTL-inducing activity of MAGE-A6 HLA-A24-binding peptides in melanoma patients.
The following MAGEA6 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
| HLA | HLA Frequency (%) | Peptide | Position | Lymphocyte Stimulation Method |
PMID |
|---|---|---|---|---|---|
| A34 | 1 | MVKISGGPR | 290-298 | autologous tumor cells | 10064076 |
| B35 | 20 | EVDPIGHVY | 168-176 | autologous tumor cells | 14634146 |
| B37 | 3 | REPVTKAEML | 127-136 | autologous tumor cells | 10363990 |
| Cw7 | 41 | EGDCAPEEK | 212-220 | lentivirus-dendritic cells | 14764691 |
| Cw16 | 7 | ISGGPRISY | 293-301 | autologous tumor cells | |
| DR13 | 19 | LLKYRAREPVTKAE | 121-134 | protein | 10049940 |
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with MAGEA6.