Protein
Gene:
MPHOSPH1 (official gene symbol)Other symbol:
MPHOSPH1CT family:
CT90CT identifier:
CT90Aliases from NCBI:
DKFZp434B0435 , DKFZp434P0810 , KRMP1 , MPP-1 , MPP1RefSeq :
Protein Names (UNIPROT)
M-phase phosphoprotein 1
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasm | COS-7 monkey cell line (interphase) | Immunofluorescence | 11470801 |
| dispersed throughout the cell | COS-7 monkey cell line (mitosis) | Immunofluorescence | 11470801 |
| cytoplasm | HeLA cell line | Immunofluorescence | 8885239 |
| nucleus | HeLA cell line (interphase) | Immunofluorescence | 12740395 |
| cytoplasm (cell cycle-dependent) | HeLA cell line (mitosis) | Immunofluorescence | 12740395 |
| nucleus | UM-UC-3 bladder cancer cell line (interphase) | IHC | 17409436 |
| cytoplasm (contractile ring) | UM-UC-3 bladder cancer cell line (telophase) | IHC | 17409436 |
Protein function and interaction
MPHOSPH1, a mitotic phosphoprotein, is a plus-end-directed kinesin-related protein with a cell cycle-regulated localization, that plays a critical role in cytokinesis (Abaza et al., 2003 PMID: 12740395). MPHOSPH1 (KRMP1) interacts with the mitotic peptidylprolyl isomerase Pin1 “in vivo”, is phosphorylated by cdc2 kinase and interacts directly with Pin1 “in vitro”. (Kamimoto et al., 2001 PMID: 11470801). MPHOSPH1 interacts with protein regulator of cytokinesis 1 (PRC1). The MPHOSPH1/PRC1 interaction may be involved in bladder carcinogenesis (Kanehira et al., 2007 PMID: 17409436).
