Protein
Gene:
PRM2 (official gene symbol)Other symbol:
PRM2CT family:
CT94CT identifier:
CT94.2Aliases from NCBI:
FLJ27447RefSeq :
Protein Names (UNIPROT)
Protamine-2 (Sperm protamine-P2) (Sperm histone P2) [Contains: Basic nuclear protein HPI1; Basic nuclear protein HPI2; Basic nuclear protein HPS1; Basic nuclear protein HPS2; Sperm histone HP4 (Sperm protamine P4); Sperm histone HP2 (Sperm protamine P2) (P2'); Sperm histone HP3 (Sperm protamine P3) (P2'')].
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| nucleus | spermatid | in situ hybridization | 7865133 |
| nucleus | spermatozoa | Immunofluorescence | 18478156 |
Protein function and interaction
The human protamine gene cluster consists of three tightly regulated genes, protamine 1 (PRM1), protamine 2 (PRM2) and transition protein 2 (TNP2). Their products are required to repackage the paternal genome during spermiogenesis into a functional gamete (Martins & Krawetz 2007 PMID: 17491138).
