Protein function and interaction

TMEFF2 gene encodes a modular protein consisting of two follistatin modules, an epidermal growth factor (EGF)-like repeat, and a transmembrane domain connected to a short cytoplasmic tail with a potential G-protein activation motif. TMEFF2 may play a role in signaling by growth factors. c-Myc represses TMEFF2 transcription in prostate cells (Gary et al., 2003 PMID: 12729735). TMEFF2 is an ADAM17 and gamma-secretase substrate, contributing to cell proliferation in an ADAM17-dependent autocrine fashion in cells expressing this protein (Ali et al., 2007 PMID: 17942404). TMEFF2-ECD induces tyrosine phosphorylation of the epidermal growth factor ErbB4 in gastric cancer cells (Uchida et al., 1999 PMID: 10600548). It is hypothesized that TR2 (TMEFF2) may participate in amyloid plaque formation and contribute to the pathogenesis of Alzheimer’s disease (Siegel et al., 2006 PMID: 16805794).