Protein

Gene:

TSPY1 (official gene symbol)

Other symbol:

TSPY3

CT family:

CT78

CT identifier:

CT78

Aliases from NCBI:

DYS14 , pJA923 , TSPY

Unified entry for genes TSPY1, LOC728137, TSPY1D, TSPY1E, TSPY1F, TSPY1G, TSPY1H, TSPY1I, TSPY2 (nearly-identical copies)

RefSeq :

NP_003299.2

Protein Names (UNIPROT)

Testis-specific Y-encoded protein 1

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
cytoplasm	COS-7 cell line	Indirect immunofluorescence	16106251
cytoplasm	spermatogonia	IHC	8923009

Protein function and interaction

TSPY plays an important role in the control of cell cycle progression, cell proliferation, and tumorigenesis (Oram et al, 2006 PMID: 16762081). TSPY binds competitively to cyclin B and colocalizes with cyclin B1 during the cell cycle, particularly on the mitotic spindles at metaphase (Li et al., 2008 PMID: 18591933). The yeast two-hybrid screen identified the translation elongation factor eEF1A as a binding partner for TSPY (Kido et al., 2008 PMID: 18649364).