| 1 |
01/18/2008 |
17977648 |
Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells. |
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Previously, we have developed a unique in vitro LNCaP cell model, which includes androgen-dependent (LNCaP-C33), androgen-independent (LNCaP-C81) and an intermediate phenotype (LNCaP-C51) cell lines r...
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| 2 |
12/01/2007 |
18055732 |
Maternal smoking: effect on circulating cell-free fetal and total DNA levels in maternal plasma from the second trimester. |
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OBJECTIVE: To estimate whether potential clinical applications of cell-free fetal and total DNA in the field of noninvasive prenatal diagnosis need to be adjusted for maternal smoking status. METHODS:...
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| 3 |
11/01/2007 |
17588179 |
Molecular characterization of a polymorphic 3-Mb deletion at chromosome Yp11.2 containing the AMELY locus in Singapore and Malaysia populations. |
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Amelogenin paralogs on Chromosome X (AMELX) and Y (AMELY) are commonly used sexing markers. Interstitial deletion of Yp involving the AMELY locus has previously been reported. The combined frequency o...
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| 4 |
10/01/2007 |
17909006 |
Fetal microchimerism in women with breast cancer. |
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Fetal microchimerism (FMc) describes long-term persistence of small numbers of fetal-derived allogeneic cells in the mother. Although FMc has been implicated as a mechanism of autoimmune disease, it m...
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| 5 |
10/01/2007 |
17881721 |
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis. |
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Y chromosome microdeletion is the most important genetic cause of impairment of spermatogenesis. Nevertheless, a significant proportion of patients with spermatogenic failure do not have this conditio...
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| 6 |
10/01/2007 |
17521702 |
The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. |
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The testis-specific protein Y-encoded (TSPY) gene is the putative gene for the gonadoblastoma locus on the Y chromosome (GBY) that predisposes dysgenetic gonads of intersex patients to gonadoblastoma ...
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| 7 |
09/01/2007 |
17875493 |
Tumor risk in disorders of sex development (DSD). |
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Disorders of sex development (DSD), previously referred to as intersex disorders, comprise a variety of anomalies defined by congenital conditions in which chromosomal, gonadal, or anatomical sex is a...
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| 8 |
08/01/2007 |
17705807 |
Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. |
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Hypotheses on the origin and distribution of extragonadal germ cell tumours (GCTs) and teratomas are briefly reviewed and revisited in the light of (i) new developments in the classification of GCTs, ...
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| 9 |
08/01/2007 |
17547684 |
Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. |
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OBJECTIVE: Gonadal karyotyping is considered a tool for increasing our knowledge of disturbed gonadal development in patients with gonadal dysgenesis and for estimating more accurately the risk for go...
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| 10 |
06/01/2007 |
17416916 |
Correlation of maternal plasma total cell-free DNA and fetal DNA levels with short term outcome of first-trimester vaginal bleeding. |
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BACKGROUND: The current methods using sonographic parameters and/or maternal serum beta-HCG levels to predict spontaneous abortion are not satisfactory. The aim of this study was to determine whether ...
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| 11 |
05/01/2007 |
17509197 |
TSPY gene copy number as a potential new risk factor for male infertility. |
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The human TSPY (testis-specific protein, Y-linked) gene family (30-60 copies) is situated in the MSY (male-specific) region of the Y chromosome. Testis-specific expression indicates that the gene play...
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| 12 |
05/01/2007 |
17286310 |
Free fetal DNA in maternal plasma in anembryonic pregnancies: confirmation that the origin is the trophoblast. |
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OBJECTIVE: To test the hypothesis that free fetal DNA (ffDNA) circulating in maternal plasma originates mainly from the placenta we studied ffDNA levels in anembryonic pregnancies. METHODS: Maternal b...
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| 13 |
04/01/2007 |
17185645 |
The origin and evolution of human ampliconic gene families and ampliconic structure. |
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Out of the nine male-specific gene families in the human Y chromosome amplicons, we investigate the origin and evolution of seven families for which gametologous and orthologous sequences are availabl...
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| 14 |
03/01/2007 |
17349529 |
Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ. |
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The testis-specific protein Y-encoded gene (TSPY) is a tandem repeat gene located at the critical region for the gonadoblastoma locus on Y chromosome that predisposes the dysgenetic gonads of intersex...
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| 15 |
03/01/2007 |
17208017 |
Molecular phylogeny and evolutionary history of Southeast Asian macaques forming the M. silenus group. |
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The 12 presently recognized taxa forming the Macaca silenus group represent the most diverse lineage within the genus Macaca. The present study was set up to clarify the phylogenetic relationships of ...
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| 16 |
02/01/2007 |
17189292 |
Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y. |
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Structural polymorphism is increasingly recognized as a major form of human genome variation, and is particularly prevalent on the Y chromosome. Assay of the Amelogenin Y gene (AMELY) on Yp is widely ...
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| 17 |
02/01/2007 |
17152117 |
Free fetal DNA in maternal circulation: a potential prognostic marker for chromosomal abnormalities? |
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OBJECTIVES: Previous studies on the association of fetal cell-free (cf)DNA levels in maternal circulation have produced conflicting results but the sample sizes were small and based on archived materi...
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| 18 |
01/01/2007 |
17566262 |
Putative human male germ cells from bone marrow stem cells. |
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Germ cells must develop along distinct male or female paths to produce the spermatozoa or oocyte required for sexual reproduction. Male germline stem cells maintain spermatogenesis in the postnatal hu...
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| 19 |
01/01/2007 |
17274819 |
Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers. |
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BACKGROUND: Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular ...
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| 20 |
12/01/2006 |
17139694 |
Detection of cell-free fetal DNA in maternal urine. |
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OBJECTIVE: To evaluate the presence of cell-free fetal DNA signals in maternal urine as a potential source of material for non-invasive prenatal diagnosis. STUDY DESIGN: Patients referred to the regio...
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