Protein
Gene:
TSP50 (non-official gene symbol)Other symbol:
TSP50CT family:
CT20CT identifier:
CT20RefSeq :
Protein Names (UNIPROT)
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasm and nuclei | early,middle, and late stage spermatocytes | IHC | 11782390 |
| ER and the cytoplasm membrane | HeLA cell line | Indirect immunofluorescence | 17283160 |
| cytoplasm and nuclei | spermatocytes | IHC | 15491742 |
Protein function and interaction
TSP50 might represent a novel type of threonine protease (Xu et al., 2007 PMID: 17283160) and may perform a critical biologic function in mammalian spermatogenesis (Xu et al., 2004 PMID: 15491742). TSP50 promoter is negatively governed by p53, suggesting that it could be an oncogene participating in the onset and progression of cancer (Xu et al., 2007 PMID: 17283160). TSP50 transcription activation is directly regulated by BORIS. BORIS-induced expression of TSP50 is governed by accessibility and binding of BORIS to the TSP50 promoter (Kosaka-Suzuki et al., 2011 PMID:21659515).
