Protein

Gene:

SPINLW1 (official gene symbol)

Other symbol:

SPINLW1

CT family:

CT71

CT identifier:

CT71

Aliases from NCBI:

dJ461P17.2 , EPPIN , EPPIN1 , EPPIN2 , EPPIN3 , WAP7 , WFDC7

RefSeq :

NP_852479.1 | NP_065131.1

Protein Names (UNIPROT)

Eppin precursor

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
tail	spermatozoa	Immunoprecipitation	17567961
acrosome, post-acrosome, midpiece and tail	spermatozoa	IHC	11404006

Protein function and interaction

Eppin coats the surface of human ejaculate spermatozoa. An eppin protein complex (EPC) containing lactotransferrin (LTF; also known as lactoferrin), clusterin (CLU), and semenogelin (SEMG1) was identified. The EPC may provide a surface network with microbicidal properties that protects spermatozoa, as well as regulates the transition to a motile, capacitated sperm (Wang et al, 2007 PMID: 17567961).