Protein
Gene:
ACRBP (official gene symbol)Other symbol:
ACRBPCT family:
CT23CT identifier:
CT23Aliases from NCBI:
OY-TES-1 , SP32RefSeq :
Protein Names (UNIPROT)
Acrosin-binding protein precursor
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| cytoplasm and nucleus | mesenchymal stem cells | IHC | 22651134 |
| acrosome (by similarity) | spermatozoa | Biochemical methods | 8144514 |
Protein function and interaction
ACRBP binds the acrosome protein proacrosin and is involved in packaging the acrosin zymogen into the acrosomal matrix (by similarity) (Baba et al., 1994 PMID: 8144514). ACRBP is phosphorylated on Tyr residues in capacitated sperm (by similarity) (Dubé et al.,2005 PMID: 15955892). In human bone marrow derived mesenchymal stem cells ACRBP (OY-TES-1) may have a role in the regulation of cell growth, apoptosis and migration (Cen et al., 2012 PMID:22651134). In cancer cells, ACRBP depletion may result in mitotic errors and reduced proliferative fitness (Whitehurst et al., 2010 PMID: 20876808).
