Protein

Gene:

DDX53 (official gene symbol)

Other symbol:

DDX53

CT family:

CT26

CT identifier:

CT26

Aliases from NCBI:

CAGE

RefSeq :

NP_874358.2

Protein Names (UNIPROT)

Probable ATP-dependent RNA helicase DDX53

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
nucleus	cervical cancer cell line C33A	Indirect immunofluorescence	11922625

Protein function and interaction

CAGE promotes motility of cancer cells through activation of Focal adhesion kinase, FAK (Shim et al, 2006a PMID:17028776) and by activating ERK and p38 MAPK, inducing catalase activity, and reducing ROS levels (Shim et al., 2006b PMID:16819299).

CAGE expression is cell cycle related, suggesting that it plays a role in cellular growth and proliferation (Cho et al., 2002 PMID: 11922625). CAGE possesses oncogenic potential and promotes cell cycle progression by inducing AP-1- and E2F-dependent expression of cyclin D1 and E (Por et al., 2010 PMID: 20220142).

CAGE regulates the expression of epithelial-mesenchymal transition (EMT)-related proteins through ERK, Akt and nuclear factor kappaB (NF-kB). CAGE also induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to anti-cancer drugs (by similarity) (Kim et al., 2009 PMID: 19322522) and induces the expression of matrix metalloproteinase-2 (MMP-2) by activating Akt, which in turn interacts with inhibitory kappa kinase beta (IkappaKbeta) to activate nuclear factor kappaB (NF-kappaB) (Kim & Jeong, 2009 PMID: 19944019).