| 1 |
10/23/2007 |
17855441 |
Differential expression of novel tyrosine kinase substrates during breast cancer development. |
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To identify novel tyrosine kinase substrates that have never been implicated in cancer, we studied the phosphoproteomics changes in the MCF10AT model of breast cancer progression using a combination o...
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| 2 |
03/01/2007 |
17332284 |
Sperm-associated antigen 9, a novel cancer testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer. |
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PURPOSE: Cancer testis antigens are a group of tumor antigens with gene expression restricted to male germ cells in the testis and in various cancerous tissues. Recently, we reported a novel testis-sp...
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| 3 |
03/01/2007 |
17317613 |
Autoantibody response against a novel testicular antigen protein highly expressed in testis (PHET) in SSc patients. |
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Systemic sclerosis (SSc) is characterized by excessive fibrosis and autoantibody production. However, the pathogenesis of SSc is still under investigation. We have demonstrated that a novel testicular...
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| 4 |
11/06/2006 |
17074887 |
Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo. |
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The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cell differentiation, but the signaling mechanisms by which it is activated during this process are largely unknown. ...
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| 5 |
07/01/2006 |
16619266 |
Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein. |
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Retinoic acid (RA) is a morphogen that induces endodermal differentiation of murine P19 embryonic carcinoma cells. RA-induced differentiation of P19 cells has been used as a model system to define the...
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| 6 |
04/24/2006 |
16061308 |
Characterization of immune response in mice to plasmid DNA encoding human sperm associated antigen 9 (SPAG9). |
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To examine the immunogenicity of the plasmid DNA encoding human sperm associated antigen 9 (hSPAG9), the cDNA corresponding to hSPAG9 was cloned in mammalian expression vector pcDNA 3.1 down stream of...
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| 7 |
02/03/2006 |
16356479 |
Small interference RNA-mediated knockdown of sperm associated antigen 9 having structural homology with c-Jun N-terminal kinase-interacting protein. |
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Recently, we reported a novel testis-specific sperm associated antigen 9 (SPAG9) protein, a new member of the JNK-interacting protein family, having a functional role in sperm-egg fusion [N. Jagadish,...
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| 8 |
11/01/2005 |
16245925 |
JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway. |
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Scaffolding proteins play a critical role in conferring specificity and fidelity to signaling pathways. The JNK-interacting leucine zipper protein (JLP) has been identified as a scaffolding protein in...
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| 9 |
10/01/2005 |
16143403 |
Immunogenicity and contraceptive potential of recombinant human sperm associated antigen (SPAG9). |
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Human sperm-associated antigen 9 (hSPAG9) is a potential target for sperm-based contraceptive vaccine in lieu of its location on the sperm acrosomal compartment and its implication in sperm-egg intera...
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| 10 |
08/26/2005 |
15987681 |
JLP associates with kinesin light chain 1 through a novel leucine zipper-like domain. |
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Scaffolding proteins exist in eukaryotes to properly assemble signaling proteins into specific multimeric functional complexes. JLP is a novel leucine zipper protein belonging to a family of scaffoldi...
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| 11 |
07/01/2005 |
15693750 |
Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. |
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We report a novel SPAG9 (sperm-associated antigen 9) protein having structural homology with JNK (c-Jun N-terminal kinase)-interacting protein 3. SPAG9, a single copy gene mapped to the human chromoso...
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| 12 |
02/13/1998 |
9480848 |
Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. |
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A novel gene coding for a human sperm surface protein (HSS) has been cloned from a human testis cDNA library. The 2.5 kb cDNA (hss) contains five direct repeats, three mirror repeats, three possible s...
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