1 |
10/01/2007 |
17909063 |
A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes. |
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The identification and functional characterization of tumor-specific genes is a prerequisite for the development of targeted cancer therapies. Using an integrated data mining and experimental validati...
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2 |
08/01/2007 |
17554801 |
Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia. |
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OBJECTIVE: To compare mRNA concentrations of corticotrophin-releasing hormone (CRH), placenta specific-1 (PLAC1), and selectin-P in preeclamptic and normal pregnancies. METHODS: Peripheral blood sampl...
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3 |
07/01/2007 |
17186554 |
The PLAC1 protein localizes to membranous compartments in the apical region of the syncytiotrophoblast. |
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PLAC1 is a trophoblast-specific gene that maps to a locus on the X-chromosome important to placental development. We have previously shown that PLAC1 gene expression is linked to trophoblast different...
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4 |
06/01/2007 |
16860456 |
PLAC1 mRNA levels in maternal blood at induction of labor correlate negatively with induction-delivery interval. |
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OBJECTIVE: This study was conducted to determine whether, in low risk women having labor induced using prostaglandin gel (dinoprostone gel), there is a relationship between the concentration of mRNA f...
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5 |
01/01/2007 |
17983203 |
PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses. |
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Identification of genes that are upregulated in tumors, and whose normal expression excludes adult somatic tissues but includes germline and/or embryonic tissues, has resulted in a rich variety of can...
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6 |
09/01/2006 |
17108202 |
PLAC1 mRNA in maternal blood correlates with Doppler waveform in uterine arteries in normal pregnancies at the second and third trimester. |
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Doppler analysis of the uterine arteries is currently used for pre-eclampsia (PE) screening. PLAC1 is a trophoblast-specific gene, and it is known that in normal pregnancies, trophoblastic cells are r...
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7 |
04/18/2006 |
16617350 |
[PLAC1/CP1 gene expression and autologous humoral immunity in gastric cancer patients] |
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OBJECTIVE: To investigate PLAC1/CP1 as a potential candidate gene in gastric cancer therapy. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) method was used to detect the expression ...
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8 |
03/01/2006 |
16594548 |
Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia. |
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In this study we have investigated whether quantitative analysis of placental mRNAs in maternal plasma provides a way to monitor placental status. We measured plasma concentrations of human chorionic ...
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9 |
01/01/2006 |
16600035 |
The PLAC1-homology region of the ZP domain is sufficient for protein polymerisation. |
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BACKGROUND: Hundreds of extracellular proteins polymerise into filaments and matrices by using zona pellucida (ZP) domains. ZP domain proteins perform highly diverse functions, ranging from structural...
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10 |
07/01/2005 |
15803460 |
PLAC1 expression increases during trophoblast differentiation: evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis. |
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PLAC1 is a recently described, trophoblast-specific gene that localizes to a region of the X-chromosome important in placental development. Immunohistochemical analysis demonstrated that PLAC1 polypep...
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11 |
01/01/2005 |
15608456 |
Rapid clearance of mRNA for PLAC1 gene in maternal blood after delivery. |
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OBJECTIVE: To evaluate (1) whether the presence of mRNA for the specific trophoblast gene PLAC1 in maternal whole blood is pregnancy-specific, and (2) whether delivery would result in the clearance of...
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12 |
01/01/2005 |
15516331 |
Lower maternal PLAC1 mRNA in pregnancies complicated with vaginal bleeding (threatened abortion <20 weeks) and a surviving fetus. |
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13 |
05/08/2003 |
12758124 |
Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. |
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Microarray expression profiling of a collection of 15,000 mouse genes with placental and embryonic RNAs revealed candidates for placental-enriched genes, three of which we have confirmed and further c...
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14 |
01/01/2003 |
12490196 |
Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cells. |
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Transplantation of nuclei (NT) from engineered mouse ES cells is a potentially powerful and rapid route to create knockout mice, obviating the need for matings to obtain germ-line chimeras. However, s...
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15 |
12/01/2002 |
12412044 |
PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. |
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Plac1, a placenta-specific gene, is expressed exclusively by cells of trophoblastic lineage in the mouse, and maps to a region of the X chromosome known to be important in placental growth. These stud...
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16 |
11/01/2001 |
11747200 |
Oosp1 encodes a novel mouse oocyte-secreted protein. |
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Oocyte-somatic cell communication is necessary for normal ovarian function. However, the identities of the majority of oocyte-secreted proteins remain unknown. A novel cDNA encoding mouse oocyte-secre...
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17 |
09/15/2000 |
10995572 |
PLAC1, an Xq26 gene with placenta-specific expression. |
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A novel human X-linked gene shows placenta-specific expression and has been named PLAC1. The gene maps 65 kb telomeric to HPRT at Xq26 and has been completely sequenced at the cDNA and genomic levels....
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