| 1 |
01/01/2008 |
17981348 |
The thrombospondin-related protein CpMIC1 (CpTSP8) belongs to the repertoire of micronemal proteins of Cryptosporidium parvum. |
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Bioinformatic data show that, in addition to TRAP-C1, Cryptosporidium parvum encodes 11 thrombospondin-related proteins (CpTSP2 through CpTSP12), none of which has been characterized yet. We describe ...
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| 2 |
12/05/2007 |
18057090 |
Thrombospondin-1 (TSP1) is an adipokine associated with obesity, adipose inflammation and insulin resistance. |
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Objectives: We examined the relationship between the expression of thrombospondin-1 (TSP1), an anti-angiogenic factor and regulator of TGF-beta activity, with obesity, adipose inflammation and insulin...
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| 3 |
12/01/2007 |
18021253 |
Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma. |
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Angiogenic switch in renal cell carcinoma (RCC) is attributed to the inactivation of the von Hippel-Lindau tumor suppressor, stabilization of hypoxia inducible factor-1 transcription factor and increa...
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| 4 |
12/01/2007 |
17916772 |
Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. |
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OBJECTIVE: Decreased blood flow secondary to peripheral vascular disease underlies a significant number of chronic diseases that account for the majority of morbidity and mortality among the elderly. ...
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| 5 |
11/21/2007 |
18032585 |
Thrombospondins Use the VLDL Receptor and a Non-Apoptotic Pathway to Inhibit Cell Division in Microvascular Endothelial Cells. |
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Monitoring Editor: Josephine Adams TSPs 1 and 2 function as endogenous inhibitors of angiogenesis. Although TSPs have been shown to induce apoptosis in HMVEC, we reasoned that a homeostatic mechanism ...
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| 6 |
11/20/2007 |
18031293 |
Prevalence of the ADAMTS13 missense mutation R1060W in late onset adult TTP. |
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Background: Thrombotic thrombocytopenic purpura (TTP) is most commonly associated with deficiency or inhibition of von Willebrand factor-cleaving protease (ADAMTS13) activity. ADAMTS13 mutations and p...
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| 7 |
11/01/2007 |
17881461 |
Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury. |
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Diabetic nephropathy is the most common cause of end-stage renal failure in the United States. Hyperglycemia is an important factor in the pathogenesis of diabetic nephropathy. Hyperglycemia upregulat...
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| 8 |
10/22/2007 |
17955499 |
High glucose levels up-regulate upstream stimulatory factor 2 gene transcription in mesangial cells. |
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Previously, we demonstrated that upstream stimulatory factor 2 (USF2) mediates high glucose-induced thrombospondin1 (TSP1) gene expression and TGF-beta activity in glomerular mesangial cells and plays...
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| 9 |
10/05/2007 |
17917789 |
Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness. |
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The single-gene approaches in association studies of polygenic diseases are likely to provide limited value in predicting risk. The combined analysis of genetic variants that interact in the same path...
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| 10 |
10/01/2007 |
17761938 |
Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation. |
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OBJECTIVE: Thrombospondin-1 (TSP1) is described as a positive regulator of vascular smooth muscle growth in cell culture. However, insight into the in vivo effects of TSP1 on smooth muscle cell (SMC) ...
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| 11 |
10/01/2007 |
17507668 |
Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan. |
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Thrombospondin-1 (TSP1) is a matricellular glycoprotein that has key roles in interactions between human cells and components of the extracellular matrix. Here we report a novel role for the lectin TS...
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| 12 |
09/15/2007 |
17540842 |
The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow. |
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ADAMTS13 cleaves von Willebrand factor (VWF) between Tyr(1605) and Met(1606) residues at the central A2 subunit. The amino-terminus of ADAMTS13 protease appears to be sufficient to bind and cleave VWF...
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| 13 |
09/01/2007 |
17760807 |
Dysregulation of CD47 and the ligands thrombospondin 1 and 2 in multiple myeloma. |
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CD47 and thrombospondin 1 and 2 (TSP1 and TSP2) expression were analysed by real-time reverse transcription polymerase chain reaction in fluorescence-activated cell sorted plasma cells (PCs) from pati...
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| 14 |
09/01/2007 |
17640965 |
A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. |
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In diabetes and hypertension, the induction of increased transforming growth factor-beta (TGF-beta) activity due to glucose and angiotensin II is a significant factor in the development of fibrosis an...
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| 15 |
09/01/2007 |
17487836 |
Androgen receptor targets NFkappaB and TSP1 to suppress prostate tumor growth in vivo. |
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The androgen role in the maintenance of prostate epithelium is subject to conflicting opinions. While androgen ablation drives the regression of normal and cancerous prostate, testosterone may cause b...
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| 16 |
07/01/2007 |
17589791 |
Participation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation. |
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Rat protein DE is an androgen-dependent cysteine-rich secretory protein (CRISP) synthesized by proximal epididymal regions. DE, also known as CRISP-1, is localized on the equatorial segment of acrosom...
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| 17 |
07/01/2007 |
17572512 |
Upregulation of thrombospondin-1(TSP-1) and its binding partners, CD36 and CD47, in sporadic inclusion body myositis. |
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The TSP1/CD36/CD47-complex is involved in T cell expansion and inflammatory responses to beta-amyloid, both relevant to IBM. We report on the mRNA and protein expression of TSP1/ CD36 /CD47-complex in...
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| 18 |
07/01/2007 |
17377140 |
Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm. |
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Cysteine-rich secretory protein (CRISP) 2 (previously TPX1) is a testis-enriched member of the CRISP family, and has been localized to both the sperm acrosome and tail. Like all members of the mammali...
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| 19 |
06/07/2007 |
17554539 |
Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer. |
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BACKGROUND: Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metrono...
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| 20 |
06/01/2007 |
17433013 |
A polymorphism within the equine CRISP3 gene is associated with stallion fertility in Hanoverian warmblood horses. |
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Fertility of stallions is of high economic importance, especially for large breeding organisations and studs. Breeding schemes with respect to fertility traits and selection of stallions at an early s...
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