| 1 |
10/30/2007 |
17971504 |
Tissue expression patterns identify mouse cilia genes. |
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In mammals, cilia are critical for development, sensation, cell signaling, sperm motility, and fluid movement. Defects in cilia are causes of several congenital syndromes, providing additional reasons...
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| 2 |
10/01/2007 |
17551920 |
A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies. |
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Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying Sperm protein 17 (Sp17) as the bait in a yeast...
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| 3 |
04/15/2007 |
17230514 |
Clinical significance of sperm protein 17 expression and immunogenicity in esophageal cancer. |
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We recently identified sperm protein 17 (Sp17) transcripts in esophageal squamous cell carcinomas (ESCCs) by differential display. This study was designed to determine the clinical significance of Sp1...
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| 4 |
04/10/2007 |
17336323 |
A NOD/SCID tumor model for human ovarian cancer that allows tracking of tumor progression through the biomarker Sp17. |
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No experimental animal model employing a primary human ovarian carcinoma (OC) cell line is presently available that tracks the progression of this cell line with an identifiable marker. This hinders i...
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| 5 |
03/01/2007 |
17309563 |
Sperm protein 17 influences the tissue-specific malignancy of clear cell adenocarcinoma in human epithelial ovarian cancer. |
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Clear cell adenocarcinoma of the ovary has a poor prognosis due to chemoresistance and early metastasis to the lymph nodes. It also can result in endometriosis and is the second most frequent type of ...
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| 6 |
01/01/2007 |
17302030 |
[Detection of anti-Sp17 antibodies in infertile patients' serum and its clinical significance] |
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OBJECTIVE: To test anti-Sp17 antibodies in the serum of AsAb positive infertile patients, to investigate the proportion of anti-Spl7 antibodies in AsAb and their potential application to the serologic...
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| 7 |
09/01/2006 |
16948914 |
[Preparation and characterization of the monoclonal antibody against human sperm protein 17] |
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AIM: To prepare and characterize the monoclonal antibody (mAb) against sperm protein 17 (Sp17). METHODS: Human Sp17 cDNA was cloned and recombinant Sp17 protein was expressed as a fusion protein with ...
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| 8 |
06/01/2006 |
16833189 |
[Development of radioimmunoassay for human sperm protein 17] |
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OBJECTIVE: To develop a method of radioimmunoassay for human sperm protein 17(Sp17) determination. METHODS: Anti-recombinant human Sp17 antibody was prepared, the labeling of 125I-rhSp17 performed by ...
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| 9 |
04/15/2006 |
16631469 |
Differentially expressed genes in the prostate cancer cell line LNCaP after exposure to androgen and anti-androgen. |
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Androgens play an important role in growth and maintenance of prostate cells. The actions of androgens are mediated by the androgen receptor (AR), a transcription factor member of the super-family of ...
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| 10 |
01/01/2006 |
16438728 |
Sperm protein 17 is expressed in human nervous system tumours. |
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BACKGROUND: Human sperm protein 17 (Sp17) is a highly conserved protein that was originally isolated from a rabbit epididymal sperm membrane and testis membrane pellet. It has recently been included i...
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| 11 |
12/01/2005 |
16311122 |
Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma. |
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Esthesioneuroblastomas (ENBs) are rare malignant tumors of the nasal vault, the origin, diagnosis, and management of which are still subjects of discussion. That there is no related prognostic factor ...
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| 12 |
09/01/2005 |
16138340 |
Cancer immunotherapy targeting Sp17: when should the laboratory findings be translated to the clinics? |
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Despite advances in chemotherapeutic agents, the prognosis for some cancers remains extremely poor, suggesting the need for other treatment modalities. Immunotherapy appears an ideal approach because ...
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| 13 |
02/01/2005 |
15599930 |
Identification of differentially expressed genes in oral squamous cell carcinoma. |
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Rapid advances in multimodality therapy have not significantly improved the overall 5-yr survival of oral cancer patients in the past two decades, thereby underscoring the need for molecular therapeut...
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| 14 |
02/01/2005 |
15385410 |
Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4. |
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The second messenger cAMP mediates its intracellular effects in spermatozoa through cAMP-dependent kinase (PKA, formally known as PRKACA). The intracellular organization of PKA in spermatozoa is contr...
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| 15 |
10/18/2004 |
15381930 |
Sp17 gene expression in myeloma cells is regulated by promoter methylation. |
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The mechanisms underlying sperm protein 17 (Sp17) gene expression in myeloma cells remained unclear. Using reverse transcription-polymerase chain reaction (RT-PCR), Sp17 transcripts were detected in A...
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| 16 |
10/01/2004 |
15347315 |
Combined real time PCR and immunohistochemical evaluation of sperm protein 17 as a cancer-testis antigen. |
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We previously identified sperm protein 17 (Sp17) as a normal testicular protein aberrantly expressed in a proportion of multiple myeloma (MM). However, recent studies have generated controversies on t...
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| 17 |
07/16/2004 |
15257753 |
Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. |
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BACKGROUND: Sperm protein 17 (Sp17) is a three-domain protein that contains: 1) a highly conserved N-terminal domain that is 45% identical to the human type II alpha regulatory subunit (RII alpha) of ...
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| 18 |
04/01/2004 |
15148930 |
[Advances in the research of sperm protein 17] |
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Sperm protein 17 (Sp17) is a testis-specific protein involved in acrosome reaction in spermatozoa. However, the Sp17 gene has been recently detected in normal non-testis tissues and malignant neoplasi...
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| 19 |
04/01/2004 |
15034007 |
Sperm protein 17 is expressed in human somatic ciliated epithelia. |
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It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of th...
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| 20 |
03/01/2004 |
14712480 |
Expression of sperm protein 17 (Sp17) in ovarian cancer. |
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Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen....
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