Gene
Gene:
CTAG1B (official gene symbol)Other symbol:
CTAG1BCT family:
CT6CT identifier:
CT6.1Aliases from NCBI:
CTAG , CTAG1 , ESO1 , LAGE-2 , LAGE2B , NY-ESO-1Unified entry for genes CTAG1B, CTAG1A (nearly-identical copies)
Gene copies
CTAG1A and CTAG1B share 100% identity in the genomic extension of the alignment of NM_139250. One copy is in the plus strand and the other in the minus strand.
NM_001327 presents 100% identity with NM_139250 but has additional 37 nt in the 5' end that do not align in the genome (either copy).
RefSeqs as of October, 2007
RefSeq
Nucleotide : NM_001327.2
Phylogenetic relationships with CT genes
This gene belongs to the CTAG family.
Gene Identification
CTAG1B was identified by immunological methods - SEREX (Chen et al., 1997 PMID: 9050879).
Gene structure and chromosomal localization
The gene contains three exons that span 8 Kb approximately, and maps to Xq28 region (Chen et al, 1997b). This is an instable genomic region. Rearrangements of NY-ESO-1 have been detected involving NEMO, a gene that causes Incontinentia Pigmenti (Aradhya et al, 2001).
Chromosome band: Xq28
See this gene in the UCSC Genome Browser :
See this gene in the NCBI Map Viewer Genome Browser :
Exon-intron structure and splicing variants
NY-ESO-1 produces one confirmed transcript of 748 bp that generates a protein of 180 a.a. (NCBI AJ275978)(Chen et al, 1997b) . A second, and putative transcript that lacks exon 2 and generates a 58 a.a, has been mentioned by some authors (Rimoldi et al, 2000, Alpen et al, 2002). Information on a third putative transcript of 748 bp, that results from a second ORF and encodes a putative protein of 142 a.a. is available at NCBI´s AceView (AJ275978).
Splicing variants documented by RefSeqs:
