Protein
Gene:
CTAG1B (official gene symbol)Other symbol:
CTAG1BCT family:
CT6CT identifier:
CT6.1Aliases from NCBI:
CTAG , CTAG1 , ESO1 , LAGE-2 , LAGE2B , NY-ESO-1Unified entry for genes CTAG1B, CTAG1A (nearly-identical copies)
RefSeq :
Protein Names (UNIPROT)
Cancer/testis antigen 1B
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| predominantly in the cytoplasm | male germ cells | IHC | 17208940 |
| nucleus and cytoplasm | melanoma cell line | Immunofluorescence | 15781633 |
| cytoplasm | melanoma cell lines | Immunofluorescence | 17137291 |
| cytoplasm | melanoma cell lines | Immunofluorescence | 10901371 |
| nucleolus | mesenchymal stem cells | Immunofluorescence | 15781633 |
| nucleus and cytoplasm | spermatogonia and primary spermatocytes | IHC | 22016418 |
Protein function and interaction
Function unkown.NY-ESO-1 interacts with the MHD (MAGE homology domain) of MAGE-C1 (Cho et al, 2006). Cartron et al., 2012 (PMID:23312906) showed that histone deacetylase (HDAC1), two DNA methyltransferases (Dnmt3b and Dnmt1) and the histone methyltransferase G9a work in a sequential process of multiprotein complexes to promote the epigenetic regulation of the NY-ESO1 gene.
Domain analysis
| pfam09341 |  | Pcc1 |
