Immune response
Gene:
GAGE1 (official gene symbol)Other symbol:
GAGE1CT family:
CT4CT identifier:
CT4.1Aliases from NCBI:
MGC33825Unified entry for genes GAGE1, GAGE12B, GAGE12C, GAGE12D, GAGE12E, GAGE12F, GAGE12G, GAGE12H, GAGE12I, GAGE12J, GAGE13, GAGE2A, GAGE4, GAGE5, GAGE6, GAGE7, GAGE8 (nearly-identical copies)
Humoral immune response
Spontaneous humoral immune responses against GAGE have been detected in cancer patients.
Cellular immune response
GAGE1 was identified by its ability to be recognized by T cells and may elicit spontaneous cellular immune responses in cancer patients (Van der Eynde et al., 1995).
The following GAGE epitope recognized by T cells has been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
| HLA | HLA Frequency (%) | Peptide | Position | Lymphocyte Stimulation Method |
PMID |
|---|---|---|---|---|---|
| Cw6 | 18 | YRPRPRRY | 9-16 | autologous tumor cells | 7544395 |
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with GAGE.