Protein
Gene:
GAGE1 (official gene symbol)Other symbol:
GAGE1CT family:
CT4CT identifier:
CT4.1Aliases from NCBI:
MGC33825Unified entry for genes GAGE1, GAGE12B, GAGE12C, GAGE12D, GAGE12E, GAGE12F, GAGE12G, GAGE12H, GAGE12I, GAGE12J, GAGE13, GAGE2A, GAGE4, GAGE5, GAGE6, GAGE7, GAGE8 (nearly-identical copies)
RefSeq :
Protein Names (UNIPROT)
G antigen 1
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| inner membrane of the nuclear envelope | fetal adrenal cortex cells, primordial germ cells of the mesonephros, malignant melanoma cells and breast carcinoma cells | IHC | 22016418 |
| nucleus and cytoplasm | gonadal primordial germ cells | IHC | 17208940 |
| nucleus | HeLa, HCT116 and MZ2-MEL cell lines | IHC | 23029259 |
| nucleus and cytoplasm | spermatogonia | IHC | 16773077 |
| nucleus and cytoplasm | spermatogonia and primary spermatocytes | IHC | 22016418 |
Protein function and interaction
A yeast two-hybrid screen identified the interaction of GAGE and GCL (human germ cell-less homolog 1). GCL can recruit GAGE proteins to the nuclear envelope. GAGE proteins can bind dsDNA directly and may have roles in higher-order chromatin reorganization and reprogramming (Gjerstorff et al., 2012 PMID:23029259). GAGE expression in cancer cell lines interferes with tumor cell migration and/or reduce cell viability (Caballero et al., 2013 PMID:2362551).
