Immune response
Gene:
SSX2 (official gene symbol)Other symbol:
SSX2CT family:
CT5CT identifier:
CT5.2aAliases from NCBI:
HD21 , HOM-MEL-40 , MGC119055 , MGC15364 , MGC3884 , SSXUnified entry for genes SSX2, SSX2b (nearly-identical copies)
Humoral immune response
SSX2 was identified by SEREX (Türeci et al., 1996).
Spontaneous humoral immune responses against SSX2 have been detected in cancer patients.
| Tumor type | Tumor stage | Frequency | Antibody detection methodology | PMID |
|---|---|---|---|---|
| Breast carcinoma | Primary tumor | 1/100(1%) | RAYS | 16094643 |
| Ovarian carcinoma | 2/109(2%) | ELISA and RAYS | 16428478 | |
| Melanoma | 2/44 (5%) | SEREX | 17893560 |
Cellular immune response
Spontaneous cellular immune responses against SSX2 were detected by Bricard et al., 2005.
The following SSX2 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
| HLA | HLA Frequency (%) | Peptide | Position | Lymphocyte Stimulation Method |
PMID |
|---|---|---|---|---|---|
| A2 | 44 | KASEKIFYV | 41-49 | autologous tumor cells | 11823502 |
| DP1 | 14 | EKIQKAFDDIAKYFSK | 19-34 | peptide | 15153546 |
| DR3 | 21 | WEKMKASEKIFYVYMKRK | 37-54 | peptide | 15596411 |
| DR4 | 24 | KIFYVYMKRKYEAMT | 45-59 | peptide | 15382048 |
| DR11 | 25 | KIFYVYMKRKYEAM | 45-58 | protein | 15085202 |
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with SSX2.