Protein
Gene:
SSX2 (official gene symbol)Other symbol:
SSX2CT family:
CT5CT identifier:
CT5.2aAliases from NCBI:
HD21 , HOM-MEL-40 , MGC119055 , MGC15364 , MGC3884 , SSXUnified entry for genes SSX2, SSX2b (nearly-identical copies)
RefSeq :
Protein Names (UNIPROT)
Protein SSX2
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| nucleus | COS-1 cell lines | Immunofluorescence | 9285793 |
| nucleus | COS7 cell lines | Immunofluorescence | 10348348 |
| associated with chromatin | COS7 cell lines | Immunofluorescence | 10348348 |
| nucleus | Hela cells | Immunofluorescence | 10749136 |
| nucleus | melanoma cell lines | Immunofluorescence | 10749136 |
| nucleus | spermatogonia and primary spermatocytes | IHC | 22016418 |
| nucleus | spermatogonia and spermatocytes | IHC | 10749136 |
| nucleus | synovial sarcoma cell line 2C4 | Immunofluorescence | 10348348 |
| nucleus | synovial sarcoma cell line CME-1 and 2C4 | c-DNA microarray/ RT-PCR | 10348348 |
Protein function and interaction
SSX2 may act as a transcriptional regulators, since in vitro experiments have shown that it acts as a transcriptional repressor when targeted to a reporter gene (Lim et al., 1998).
Yeast two-hybrid system experiments identified two SSX2-interacting proteins, RAB3IP, the human homolog of an interactor of the Ras-like GTPase Rab3A; and, SSX2IP. Both RAB3IP and SSX2IP interact with the N-terminal moiety of the SSX2 protein (de Bruihn et al., 2002 PMID: 12007189). LIM homeobox protein LHX4 was also identified among the proteins that interact with the SSX C-terminal repression domain (de Bruijn et al., 2008 PMID: 17667940).
SSX2 may be fused to the SYT gene as a result of the t(X;18) translocation in synovial sarcoma (Clark et al., 1994).