| 1 |
12/01/2007 |
17929270 |
Inducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor. |
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BACKGROUND: Active immunotherapies are one approach being developed as novel treatments for prostate cancer. Critical to the success of these therapies is the identification of appropriate target anti...
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| 2 |
11/29/2007 |
18050305 |
Further characterization of the first seminoma cell line TCam-2. |
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Testicular germ cell tumors of adolescents and adults (TGCTs) can be classified into seminomatous and nonseminomatous tumors. Various nonseminomatous cell lines, predominantly embryonal carcinoma, hav...
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| 3 |
11/23/2007 |
17904521 |
SSX2IP: An emerging role in cancer. |
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We describe the emerging role of Synovial Sarcoma X breakpoint 2 Interacting Protein (SSX2IP) in cancer and its still largely unknown function in human cells. In rodents, SSX2IP has been shown to play...
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| 4 |
10/01/2007 |
17895746 |
Anaplastic sarcoma of the kidney: a clinicopathologic study of 20 cases of a new entity with polyphenotypic features. |
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We report 20 cases of a distinct, previously unrecognized renal neoplasm, anaplastic sarcoma of the kidney with polyphenotypic features. The tumors were identified by re-reviewing tumors with unusual ...
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| 5 |
10/01/2007 |
17686994 |
The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. |
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Synovial sarcoma is a soft tissue cancer associated with a recurrent t(X:18) translocation that generates one of two fusion proteins, SYT-SSX1 or SYT-SSX2. In this study, we demonstrate that SYT-SSX2 ...
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| 6 |
09/01/2007 |
18070443 |
[Detection of chromosomal aberration in paraffin-embedded synovial sarcoma tissues by fluorescence in-situ hybridization] |
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OBJECTIVE: To evaluate the application of fluorescence in-situ hybridization (FISH) in detection of gene translocation in paraffin-embedded tissue samples of synovial sarcoma. METHODS: Interphase FISH...
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| 7 |
09/01/2007 |
17721327 |
A novel variant of SYT-SSX1 fusion gene in a case of spindle cell synovial sarcoma. |
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Synovial sarcoma (SS) is a rare soft-tissue tumor that affects children and young adults. It is characterized by chromosomal translocation t(X;18)(p11.2;q11.2), which results in the fusion of the gene...
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| 8 |
09/01/2007 |
17707262 |
Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors. |
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Mixed epithelial stromal tumor of the kidney (MEST)/adult cystic nephroma (CN) is a lesion characterized by epithelial lined tubular or cystic structures interspersed within a variably prominent, dist...
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| 9 |
08/01/2007 |
17186289 |
Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individuals. |
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Proteins encoded by genes of the SSX family are specifically expressed in tumors and are therefore relevant targets for cancer immunotherapy. One of the first identified family members, SSX-1, is expr...
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| 10 |
07/30/2007 |
17667940 |
The C terminus of the synovial sarcoma-associated SSX proteins interacts with the LIM homeobox protein LHX4. |
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As a result of the synovial sarcoma-associated t(X;18) translocation, the SS18 gene on chromosome 18 is fused to either one of the three closely related SSX genes on the X chromosome. The SS18 protein...
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| 11 |
07/18/2007 |
17320278 |
Potential target antigens for immunotherapy in human pancreatic cancer. |
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BACKGROUND: To be effective and selective, immunotherapy ideally targets specifically tumor cells and spares normal tissues. Identification of tumor specific antigens is a prerequisite to establish an...
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| 12 |
07/01/2007 |
17845763 |
[Roles of immunohistochemistry and detection of SYT-SSX fusion gene in diagnosis of synovial sarcoma] |
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OBJECTIVE: To assess the diagnostic values of immunohistochemistry and SYT-SSX fusion gene detection for synovial sarcoma. METHODS: Based on clinical features, histological and immunohistochemical pro...
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| 13 |
07/01/2007 |
17609629 |
Primary pericardial synovial sarcoma confirmed by molecular genetic studies: a case report. |
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Primary pericardial synovial sarcoma is an extremely rare tumor. The awkward tumor site and clinical features associated with quite advanced disease at presentation make obtaining adequate biopsy mate...
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| 14 |
06/20/2007 |
17637219 |
Expression of SSX-1 and NY-ESO-1 mRNA in tumor tissues and its corresponding peripheral blood expression in patients with hepatocellular carcinoma. |
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BACKGROUND: Cancer-testis antigen (CTA) is a family of the most noticeable tumor antigens which could be potential tumor markers for cancer diagnosis. In this research we aimed to investigate the expr...
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| 15 |
06/01/2007 |
17509396 |
Primary monophasic synovial sarcoma of the duodenum with SYT/SSX2 type of translocation. |
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Recent findings on the molecular background of synovial sarcoma with the description of the specific translocation t(X;18) led to the incorporation of this particular genetic aberration into the defin...
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| 16 |
06/01/2007 |
17507990 |
SYT-SSX fusion is absent in sarcomatoid mesothelioma allowing its distinction from synovial sarcoma of the pleura. |
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The diagnosis of sarcomatoid mesothelioma is still a worldwide challenge and it is often difficult, both clinically and by morphological analysis, to differentiate sarcomatoid mesothelioma from synovi...
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| 17 |
06/01/2007 |
17333282 |
Loss of SLC38A5 and FTSJ1 at Xp11.23 in three brothers with non-syndromic mental retardation due to a microdeletion in an unstable genomic region. |
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Using high resolution X chromosome array-CGH we identified an interstitial microdeletion at Xp11.23 in three brothers with moderate to severe mental retardation (MR) without dysmorphic features. The e...
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| 18 |
06/01/2007 |
16960690 |
Molecular and immunological evaluation of the expression of cancer/testis gene products in human colorectal cancer. |
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Tumor-specific gene products, such as cancer/testis (CT) antigens, constitute promising targets for the development of T cell vaccines. Whereas CT antigens are frequently expressed in melanoma, their ...
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| 19 |
05/01/2007 |
17334346 |
Immunostaining for SYT protein discriminates synovial sarcoma from other soft tissue tumors: analysis of 146 cases. |
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Synovial sarcoma in its classic biphasic form can be distinguished readily from other soft tissue lesions; however, monophasic and poorly differentiated forms are diagnostically more problematic. For ...
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| 20 |
04/01/2007 |
17418413 |
A conditional mouse model of synovial sarcoma: insights into a myogenic origin. |
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Synovial sarcoma is an aggressive soft-tissue malignancy marked by a unique t(X;18) translocation leading to expression of a chimeric SYT-SSX fusion protein. We report here a mouse model of synovial s...
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