Immune response
Gene:
SSX4 (official gene symbol)Other symbol:
SSX4CT family:
CT5CT identifier:
CT5.4Aliases from NCBI:
MGC119056 , MGC12411Unified entry for genes SSX4, SSX4B (nearly-identical copies)
Humoral immune response
Spontaneous humoral immune responses against SSX4 have been detected in cancer patients.
| Tumor type | Tumor stage | Frequency | Antibody detection methodology | PMID |
|---|---|---|---|---|
| Ovarian carcinoma | 1/44(2.3%) | ELISA | 15603546 | |
| Ovarian carcinoma | 2/10 (2%) | ELISA and RAYS | 16428478 |
Cellular immune response
SSX-4-specific CD4+ T cells were detected in melanoma patients by Ayyoub et al., 2005 PMID: 15814740. The following SSX4 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
HLA
HLA Frequency (%)
Peptide
Position
Lymphocyte
Stimulation
Method PMID
DP10 2 INKTSGPKRGKHAWTHRLRE 151-170 peptide 15814740 DR3 21 YFSKKEWEKMKSSEKIVYVY 31-50 peptide 15814740 DR8 4 MKLNYEVMTKLGFKVTLPPF 51-70 peptide 16428478 DR8 4 KHAWTHRLRERKQLVVYEEI 161-180 peptide 16428478 DR11 25 LGFKVTLPPFMRSKRAADFH 61-80 peptide 15814740 DR15 20 KSSEKIVYVYMKLNYEVMTK 41-60 peptide 15814740 DR52 41 KHAWTHRLRERKQLVVYEEI 161-180 peptide 16428478
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with SSX4.