Immune response
Gene:
XAGE1 (official gene symbol)Other symbol:
XAGE1CT family:
CT12CT identifier:
CT12.1aAliases from NCBI:
GAGED2 , XAGE-1Unified entry for genes XAGE1, XAGE1B, XAGE1C, XAGE1D, XAGE1E (nearly-identical copies)
Humoral immune response
Spontaneous humoral immune responses against XAGE1 have been detected in cancer patients.
Tumor type | Tumor stage | Frequency | Antibody detection methodology | PMID |
---|---|---|---|---|
Prostate carcinoma | 1/20(5%) | Detection of protein in M13 phage | 14747957 | |
Lung carcinoma | 8/32(25%) | SEREX | 14696120 | |
Prostate carcinoma | 0/149(0%) | ELISA | 15905609 | |
Prostate carcinoma | 2/129(1.5%) | ELISA | 15905609 | |
Non small cell lung carcinoma | 8/87 (9%) | ELISA | 22922091 |
Cellular immune response
Zhou et al., 2008 (PMID: 18803763) observed the induction of XAGE-1b-specific CTLs against lung cancer cells obtained directly from patients with NSCLC using DCs pulsed with full-length XAGE-1b.