1 |
12/01/2007 |
17994469 |
Identification of methylation-silenced genes in colorectal cancer cell lines: Genomic screening using oligonucleotide arrays. |
|
|
Objective. Aberrant methylation of promoter CpG islands is associated with the loss of expression of tumor suppressor genes in human cancers. The purpose of this study was to examine methylation-silen...
|
2 |
11/20/2007 |
18045611 |
Identification of prostate cancer antigens by automated high-throughput filter immunoscreening. |
|
|
There is a need for earlier and more accurate cancer diagnostics as well as new targets for cancer immunotherapy. To this end, it is important to identify sets of tumour antigens specific for differen...
|
3 |
01/01/2007 |
17704638 |
HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells. |
|
|
XAGE-1b belongs to cancer/testis (CT) antigens, and has been shown to be expressed frequently in lung cancers and to elicit an antibody response in patients with XAGE-1b-expressing tumors. In this stu...
|
4 |
01/01/2007 |
17335148 |
Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. |
|
|
XAGE-1 is a cancer/testis (CT) antigen and has been shown to be immunogenic in lung cancer patients. Among 4 alternative splicing variants, XAGE-1a, b, c and d, XAGE-1b mRNA was dominantly expressed i...
|
5 |
11/02/2006 |
16715135 |
Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b. |
|
|
We examined the function of two key DNA methyltransferase (DNMT) enzymes in epigenetic regulation of X-linked cancer/germline (CG-X) antigen genes in human cancer cells, using MAGE-A1, NY-ESO-1, and X...
|
6 |
10/01/2006 |
16671088 |
Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines. |
|
|
In gastric cancer, increasing numbers of genes have been reported to be silenced by aberrant methylation. However, global analysis of epigenetic inactivation in cancer cells has rarely been performed....
|
7 |
04/15/2006 |
16638849 |
Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia. |
|
|
Background: Monitoring of minimal residual disease (MRD) has become a strong diagnostic tool in acute lymphoblastic leukemia. It is used for risk-adapted therapy and for the recognition of pending rel...
|
8 |
01/01/2006 |
16468707 |
Characterization of preexisting humoral immunity specific for two cancer-testis antigens overexpressed at the mRNA level in non-small cell lung cancer. |
|
|
In order to establish a rationale for immunotherapy for lung cancer, we have investigated immunological characteristics of tumor-associated antigens (TAAs) discovered through molecular approaches. Pre...
|
9 |
08/20/2005 |
15800911 |
Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation. |
|
|
Expression of the XAGE-1 antigen is restricted to germ cells of the testis and a variety of neoplastic tissues. To date, the molecular mechanism for regulating expression of this cancer/testis antigen...
|
10 |
08/01/2005 |
16061866 |
XAGE-1 expression in non-small cell lung cancer and antibody response in patients. |
|
|
PURPOSE: XAGE-1 was originally identified by the search for PAGE/GAGE-related genes using expressed sequence tag database and was shown to exhibit characteristics of cancer/testis-like antigens. Four ...
|
11 |
01/01/2005 |
15905609 |
XAGE-1 mRNA expression in prostate cancer and antibody response in patients. |
|
|
To evaluate the feasibility of cancer vaccine targeting XAGE-1, we investigated the expression of 4 XAGE-1 transcript variants and the humoral immune response to XAGE-1 in prostate cancer patients. XA...
|
12 |
05/01/2004 |
14747957 |
Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display. |
|
|
Serological cloning of tumor-associated antigens (TAAs) using patient autoantibodies and tumor cDNA expression libraries (SEREX) has identified a wide array of tumor proteins eliciting B-cell response...
|
13 |
02/10/2004 |
14696120 |
Immunoscreening of a cDNA library from a lung cancer cell line using autologous patient serum: Identification of XAGE-1b as a dominant antigen and its immunogenicity in lung adenocarcinoma. |
|
|
By serologic identification of antigens by recombinant expression cloning (SEREX) analysis using an autologous lung adenocarcinoma cell line, OU-LU-6, as a cDNA library source, we demonstrated that XA...
|
14 |
05/20/2002 |
11992404 |
The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. |
|
|
The existence of XAGE genes was first reported after database homology searches for PAGE-like sequences identified 3 XAGE EST clusters. One of these clusters, XAGE-1, has in later studies been identif...
|
15 |
05/01/2002 |
12479262 |
Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. |
|
|
Cancer testis (CT) antigens have an expression pattern that is predominantly restricted to testis in normal tissues, yet they are expressed in many different histological types of cancers. One previou...
|
16 |
01/10/2002 |
11774264 |
Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis. |
|
|
Suppression subtractive hybridization, comparing mRNA expression profiles of common nevocellular nevi and melanoma metastases, was used to identify potential markers of melanoma progression. From the ...
|
17 |
11/22/2001 |
11753648 |
L552S, an alternatively spliced isoform of XAGE-1, is over-expressed in lung adenocarcinoma. |
|
|
Using a combination of cDNA subtraction and microarray analysis, we report here the identification and characterization of L552S, an over-expressed, alternatively spliced isoform of XAGE-1 in lung ade...
|
18 |
09/01/2000 |
10987281 |
XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. |
|
|
Our previous expressed sequence tag database analysis indicates that XAGE-1 is frequently found in Ewing's sarcoma and alveolar rhabdomyosarcoma (U. Brinkmann et al., Cancer Res., 59: 1445-1448, 1999)...
|
19 |
04/01/1999 |
10197611 |
Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. |
|
|
We have developed a computer-based screening strategy to search the dbEST database to find differentiation antigens that are expressed by cancers arising in nonessential normal tissues such as prostat...
|