Immune response
Gene:
MAGEC2 (official gene symbol)Other symbol:
MAGEC2CT family:
CT10CT identifier:
CT10Aliases from NCBI:
CT10 , HCA587 , MGC13377Humoral immune response
MAGEC2 was identified by SEREX (Güre et al., 2000).Spontaneous humoral immune responses against MAGEC2 have been analysed in cancer patients.
| Tumor type | Tumor stage | Frequency | Antibody detection methodology | PMID |
|---|---|---|---|---|
| Breast carcinoma | 0/100(0%) | RAYS | 16094643 | |
| Light-chain amyloidosis (AL amyloidosis) | 0/35 (0%) | ELISA | 22983433 |
Cellular immune response
Spontaneous T cell responses in cancer patients against MAGEC2 were detected by Germeau et al., 2005 (PMID: 15657293). MAGEC2 induces specific T-cell responses in a significant proportion of hepatocellular carcinoma patients. HLA-A(*)0201-restricted cytotoxic T cell epitopes were identified (Xing et al., 2008 PMID: 18498761).
The following MAGEC2 epitopes recognized by T cells have been identified after stimulation of lymphocytes in vitro (Cancer Immunity Peptide Database).
| HLA | HLA Frequency (%) | Peptide | Position | Lymphocyte Stimulation Method |
PMID |
|---|---|---|---|---|---|
| A2 | 44 | LLFGLALIEV | 191-200 | autologous tumor cells | 14999777 |
| A2 | 44 | ALKDVEERV | 336-344 | autologous tumor cells | 14999777 |
| B44 | 21 | SESIKKKVL | 307-315 | autologous tumor cells | 17096150 |
Induced immune response
There are no published reports that evaluated induced immune responses in patients vaccinated with MAGEC2.