| 1 |
02/01/2007 |
17023585 |
Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. |
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Immunotherapies using cancer-testis (CT) antigens as targets represent a potentially useful treatment in patients with multiple myeloma (MM) who commonly show recurrent disease following chemotherapy....
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| 2 |
09/15/2006 |
17000678 |
Cancer-testis antigens: expression and correlation with survival in human urothelial carcinoma. |
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PURPOSE: Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. Cancer-testis antigens (CTA), a family of tumor-associated antigens,...
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| 3 |
09/01/2006 |
16929165 |
Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. |
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Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
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| 4 |
01/01/2006 |
16594646 |
Generation of monoclonal antibodies to cancer/testis (CT) antigen CT10/MAGE-C2. |
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CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our k...
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| 5 |
09/01/2005 |
16438850 |
[The expression of 11 cancer/testis (CT) antigen genes in esophageal carcinoma] |
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OBJECTIVE: To investigate the expression status of 11 different cancer/testis (CT) antigen genes in esophageal carcinoma. METHODS: Esophageal carcinoma tissue and adjacent normal esophageal mucosa tak...
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| 6 |
05/01/2005 |
15807856 |
Identification of a new HLA-A*0201-restricted CD8+ T cell epitope from hepatocellular carcinoma-associated antigen HCA587. |
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For the development of peptide-based cancer immunotherapies, we aimed to identify specific HLA-A*0201-restricted CTL epitopes in hepatocellular carcinoma (HCC) associated antigen HCA587, which has bee...
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| 7 |
03/01/2005 |
15756003 |
Expression profile of cancer-testis genes in 121 human colorectal cancer tissue and adjacent normal tissue. |
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PURPOSE: Among tumor antigens identified to date, cancer-testis (CT) antigens, which are coded by CT genes, are identified as a group of highly attractive targets for cancer vaccines. This study is th...
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| 8 |
11/01/2004 |
15541044 |
Elicitation of both CD4 and CD8 T-cell-mediated specific immune responses to HCA587 protein by autologous dendritic cells. |
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We recently cloned a new member of cancer/testis antigen named HCA587, which was highly expressed in human hepatocellular carcinoma (HCC) tissues. To investigate it as a potential tumour-specific targ...
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| 9 |
07/15/2004 |
15237429 |
Expression of cancer-testis antigens in hepatocellular carcinoma. |
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AIM: To investigate the expression of cancer-testis (CT) antigens MAGE-1, SSX-1,CTp11 and HCA587 genes in hepatocellular carcinoma (HCC) and the possibility of applying these antigens as targets for s...
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| 10 |
03/17/2004 |
15061963 |
[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery] |
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OBJECTIVE: To investigate the possibility of utilizing cancer-testi (CT) antigens as targets for immunotherapy of non-small cell lung cancer (NSCLC) with vaccines. METHODS: Tissues from 51 NSCLC patie...
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| 11 |
08/01/2003 |
12920247 |
HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma. |
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The HCA587 gene, identified by serological analysis of recombinant cDNA expression library (SEREX) from a hepatocellular carcinoma (HCC) patient, encodes a new member of cancer-testis antigens. HCA587...
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| 12 |
07/01/2003 |
12921655 |
[Expression and clinical significance of hepatocellular cancer antigen genes in human hepatocellular carcinoma] |
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OBJECTIVE: To investigate the expression of four hapatocellular cancer antigen (HCA) gene mRNA in hepatocellular carcinoma. METHODS: The expression of HCA90, HCA519, HCA520, HCA587 mRNA was detected u...
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| 13 |
04/01/2003 |
12679909 |
Expression, purification and serological analysis of hepatocellular carcinoma associated antigen HCA587 in insect cells. |
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AIM: In order to assess hepatocellular carcinoma associated antigen HCA587 as a potential target for immunotherapy, the Bac-to-Bac expression system was used to express recombinant protein HCA587 in i...
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| 14 |
03/04/2003 |
12601173 |
Immunomic analysis of human sarcoma. |
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The screening of cDNA expression libraries from human tumors with serum antibody (SEREX) has proven to be a powerful method for identifying the repertoire of tumor antigens recognized by the immune sy...
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| 15 |
07/15/2002 |
12097419 |
Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. |
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Autoantibodies are often detected in hepatocellular carcinoma (HCC), and these responses may represent recognition of tumor Ags that are associated with transformation events. The identities of these ...
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| 16 |
03/31/2000 |
10704737 |
Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9. |
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In an effort to define new cancer-testis (CT) genes, we investigated whether BRDT, a testis-restricted member of the RING3 family of transcriptional regulators, is also expressed in cancer. Standard R...
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| 17 |
03/01/2000 |
10699956 |
CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis. |
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Assays relying on humoral or T-cell-based recognition of tumor antigens to identify potential targets for immunotherapy have led to the discovery of a significant number of immunogenic gene products, ...
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