Protein

Gene:

SPO11 (official gene symbol)

Other symbol:

SPO11

CT family:

CT35

CT identifier:

CT35

Aliases from NCBI:

MGC39953

RefSeq :

NP_937998.1 | NP_036576.1

Protein Names (UNIPROT)

Meiotic recombination protein SPO11

Cellular localization

Subcellular Localization	Cell type	Methodology	PMID
nucleus/chromatin (by similarity)	Saccharomyces cerevisiae cells	ChIP	15655113

Protein function and interaction

SPO11 proteins have conserved functions in a number of organisms in generating sites of double-stranded DNA breaks (DSBs) that are thought to be the starting points of homologous recombination, which is required for proper segregation of chromosomes and the generation of genetic diversity during meiosis (Romanienko & Camerini-Otero, 1999 PMID: 10534401; Li & Ma, 2006 PMID: 16699536).