1 |
11/30/2007 |
18081428 |
Excess single-stranded DNA inhibits meiotic double-strand break repair. |
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During meiosis, self-inflicted DNA double-strand breaks (DSBs) are created by the protein Spo11 and repaired by homologous recombination leading to gene conversions and crossovers. Crossover formation...
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2 |
10/05/2007 |
17921483 |
Protist Homologs of the Meiotic Spo11 Gene and Topoisomerase VI Reveal an Evolutionary History of Gene Duplication and Lineage-Specific Loss. |
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Spo11 is a meiotic protein of fundamental importance as it is a conserved meiosis-specific transesterase required for meiotic recombination initiation in fungi, animals and plants. Spo11 is homologous...
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3 |
06/01/2007 |
17428461 |
Germline stem cells and neo-oogenesis in the adult human ovary. |
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It remains unclear whether neo-oogenesis occurs in postnatal ovaries of mammals, based on studies in mice. We thought to test whether adult human ovaries contain germline stem cells (GSCs) and undergo...
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4 |
05/15/2007 |
17456548 |
Characterization of Spo11-dependent and independent phospho-H2AX foci during meiotic prophase I in the male mouse. |
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Meiotic DNA double strand breaks (DSBs) are indicated at leptotene by the phosphorylated form of histone H2AX (gamma-H2AX). In contrast to previous studies, we identified on both zygotene and pachyten...
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5 |
01/01/2007 |
17674145 |
The multiple roles of the Mre11 complex for meiotic recombination. |
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During the first meiotic prophase, numerous DNA double-strand breaks (DSB) are formed in the genome in order to initiate recombination between homologous chromosomes. The conserved Mre11 complex, form...
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6 |
01/01/2007 |
17264124 |
Meiotic association between Spo11 regulated by Rec102, Rec104 and Rec114. |
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Meiotic recombination is initiated by DNA double-stranded break (DSB) formation catalyzed by Spo11, a type-II topoisomerase-like transesterificase, presumably via a dimerization-mediated mechanism. We...
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7 |
09/01/2006 |
16929165 |
Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. |
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Cancer-Testis (CT) antigens are by definition expressed in tumor but not in healthy tissue except testis and might represent ideal targets for antigen-specific immunotherapy. Here, we present the firs...
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8 |
08/01/2006 |
16856850 |
Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. |
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Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks...
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9 |
07/01/2006 |
16816334 |
Gene expression profiles of Spo11-/- mouse testes with spermatocytes arrested in meiotic prophase I. |
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Spo11, a meiosis-specific protein, introduces double-strand breaks on chromosomal DNA and initiates meiotic recombination in a wide variety of organisms. Mouse null Spo11 spermatocytes fail to synapse...
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10 |
07/01/2006 |
16728342 |
The genetics of male infertility: a field of study whose time is now. |
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Idiopathic male infertility is often associated with genetic and epigenetic abnormalities. Such abnormalities include chromosome translocations and aneuploidies, Y chromosome microdeletions, and mutat...
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11 |
05/01/2006 |
16699536 |
Double-stranded DNA breaks and gene functions in recombination and meiosis. |
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Meiotic prophase I is a long and complex phase. Homologous recombination is an important process that occurs between homologous chromosomes during meiotic prophase I. Formation of chiasmata, which hol...
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12 |
05/01/2006 |
16495306 |
An azoospermic man with a double-strand DNA break-processing deficiency in the spermatocyte nuclei: case report. |
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BACKGROUND: The mechanisms of meiotic arrest in human spermatogenesis are poorly known. METHODS AND RESULTS: A testicular biopsy from an azoospermic male showed complete spermatogenesis arrest at the ...
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13 |
09/01/2005 |
16169419 |
Screening the SPO11 and EIF5A2 genes in a population of infertile men. |
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Populations of infertile and fertile men were screened for mutations in SPO11 and EIF5A2, two infertility candidate genes. Three heterozygous amino acid changes that might contribute to infertility we...
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14 |
08/18/2005 |
16107854 |
Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. |
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DNA double-strand breaks (DSBs) with protein covalently attached to 5' strand termini are formed by Spo11 to initiate meiotic recombination. The Spo11 protein must be removed for the DSB to be repaire...
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15 |
08/15/2005 |
16009511 |
A DNA binding motif of meiotic recombinase Rec12 (Spo11) defined by essential glycine-202, and persistence of Rec12 protein after completion of recombination. |
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The Rec12 (Spo11) protein of the fission yeast Schizosaccharomyces pombe is a meiosis-specific ortholog of the catalytic subunit of type VI topoisomerases and is thought to catalyze double-strand DNA ...
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16 |
08/01/2005 |
16055729 |
Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage. |
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Fundamentally different recombination defects cause apoptosis of mouse spermatocytes at the same stage in development, stage IV of the seminiferous epithelium cycle, equivalent to mid-pachynema in nor...
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17 |
08/01/2005 |
15998665 |
SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. |
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SPO11 introduces double-strand breaks (DSBs) that trigger the phosphorylation of H2AX during meiotic prophase. In mice, SPO11 is strictly required for initiation of meiotic recombination and synapsis,...
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18 |
05/06/2005 |
15879219 |
A synaptonemal complex protein promotes homology-independent centromere coupling. |
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We describe a process in meiotic cells of budding yeast in which chromosomes become joined together in pairs at their centromeres independent of chromosomal homology. These centromeric interactions de...
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19 |
01/18/2005 |
15640358 |
Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants. |
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Defects in meiotic recombination in many organisms result in arrest because of activation of a meiotic checkpoint(s). The proximal defect that triggers this checkpoint in mammalian germ cells is not u...
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20 |
01/15/2005 |
15655113 |
The control of Spo11's interaction with meiotic recombination hotspots. |
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Programmed double-strand breaks (DSBs), which initiate meiotic recombination, arise through the activity of the evolutionary conserved topoisomerase homolog Spo11. Spo11 is believed to catalyze the DN...
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