Protein
Gene:
CASC5 (official gene symbol)Other symbol:
CASC5CT family:
CT29CT identifier:
CT29Aliases from NCBI:
AF15Q14 , D40 , KIAA1570RefSeq :
Protein Names (UNIPROT)
Protein CASC5
Cellular localization
| Subcellular Localization | Cell type | Methodology | PMID |
|---|---|---|---|
| kinetochore | HeLA cell line | Immunofluorescence | 18045986 |
| nucleus | primary spermatocytes | IHC | 15579588 |
| acrosomes (outside the acrosome membrane) | spermatids | IHC | 15579588 |
Protein function and interaction
CASC5 binds to the hMis12 kinetochore core complex, which is required for normal chromosome alignment and segregation during mitosis (Obuse et al., 2004 PMID: 15502821). CASC5 localizes to kinetochores throughout mitosis and is required for the localization of a subset of outer kinetochore proteins (Cheeseman et al., 2008 PMID: 18045986). CASC5 directly links spindle checkpoint proteins BubR1 and Bub1 to kinetochores and is required for spindle checkpoint and chromosome alignment (Kiyomitsu et al., 2007 PMID: 17981135).
Domain analysis
