1 |
11/01/2007 |
17981135 |
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. |
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The spindle checkpoint controls mitotic progression. Checkpoint proteins are temporally recruited to kinetochores, but their docking site is unknown. We show that a human kinetochore oncoprotein, AF15...
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2 |
12/01/2004 |
15579588 |
The protein encoded by cancer/testis gene D40/AF15q14 is localized in spermatocytes, acrosomes of spermatids and ejaculated spermatozoa. |
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We have previously identified and cloned a human gene, D40, that is preferentially expressed in testis among normal organs, while it is widely expressed in various human tumor cell lines and primary t...
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3 |
11/01/2004 |
15502821 |
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. |
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Defects in kinetochore proteins often lead to aneuploidy and cancer. Mis12-Mtw1 is a conserved, essential kinetochore protein family. Here, we show that a Mis12 core complex exists in Schizosaccharomy...
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4 |
03/06/2003 |
12618766 |
A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene MPFYVE on chromosome 15. |
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The mixed lineage leukemia gene (MLL, also known as HRX, ALL-1 and Htrx) located at 11q23 is involved in translocations with over 40 different chromosomal bands in a variety of leukemia subtypes. Here...
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5 |
06/05/2002 |
12087463 |
Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers. |
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We found a significant correlation between lung cancer in smokers and the expression of a human gene, D40, predominantly expressed in testis and cancers. In an attempt to clone a novel human gene, we ...
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6 |
03/01/2002 |
11857474 |
Isolation of the peri-acrosomal plasma membrane protein D40 enriched fraction from guinea pig spermatozoa using a monoclonal antibody. |
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Membrane fragments were obtained from guinea pig spermatozoa by mechanical shearing. A membrane-enriched fraction was separated from other cellular debris, mainly sperm nuclei and tails, by centrifuga...
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7 |
09/07/2000 |
10980622 |
AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14). |
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In haematopoietic malignancies the MLL gene, located on chromosome 11q23, is frequently disrupted by chromosome rearrangement, generally resulting in fusion to various partner genes. We have previousl...
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8 |
01/01/1999 |
10780384 |
Chromosomal assignment of a novel human gene D40. |
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We have previously reported an identification of a novel human cellular factor, D40. Here, we report the chromosomal localization of the gene that encodes D40. Fluorescent in situ hybridization (FISH)...
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9 |
01/01/1999 |
10780383 |
Isolation of cDNAs that cover the entire coding region of a novel human protein D40. |
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Previously, we have reported a novel protein, D40, that specifically binds to a nuclear factor GCF by two-hybrid system. Northern analysis on tumor cell lines revealed that mRNA of D40 is about 5 kb. ...
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