1 |
10/01/2007 |
17728347 |
The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation. |
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Brdt is a testis-specific member of the distinctive BET sub-family of bromodomain motif-containing proteins, a motif that binds acetylated lysines and is implicated in chromatin remodeling. Its expres...
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2 |
02/01/2007 |
17049203 |
Bromodomain testis-specific protein is expressed in mouse oocyte and evolves faster than its ubiquitously expressed paralogs BRD2, -3, and -4. |
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By using in silico methods in a previous study, we identified 100 oocyte-specific genes and 150 genes, enriched in the mouse oocyte. Interestingly, approximately half of the oocyte-specific genes tend...
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3 |
05/15/2006 |
16353146 |
Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer. |
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Cancer/germline (CG) antigens represent promising targets for widely applicable mono- and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC). Since little is known about their composit...
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4 |
01/01/2006 |
16568954 |
Histone acetylation-mediated chromatin compaction during mouse spermatogenesis. |
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One of the most dramatic chromatin remodelling events takes place during mammalian spermatogenesis involving massive incorporation of somatic and testis-specific histone variants, as well as generaliz...
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5 |
04/01/2005 |
15826242 |
CD109 expression in squamous cell carcinoma of the uterine cervix. |
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CD109 is a cell surface protein, a member of the alpha(2) macroglobulin/C3,C4,C5 family of thioester-containing proteins. The authors have recently reported that high expression of the CD109 gene was ...
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6 |
02/01/2005 |
15647849 |
Molecular cloning and expression of a novel alternative splice variant of BRDT gene. |
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In this study, a human adult testis cDNA microarray was constructed and hybridized with (33)P-labeled human adult testis, embryo testis and sperm cDNA probes, respectively. A novel alternative splice ...
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7 |
09/01/2004 |
15261828 |
Identification of unique, differentiation stage-specific patterns of expression of the bromodomain-containing genes Brd2, Brd3, Brd4, and Brdt in the mouse testis. |
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The bromodomain, an evolutionarily conserved motif that binds acetyl-lysine on histones, is found in many chromatin-associated proteins, transcription factors, and in nearly all known histone acetyltr...
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8 |
08/01/2003 |
12861021 |
Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein. |
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The association between histone acetylation and replacement observed during spermatogenesis prompted us to consider the testis as a source for potential factors capable of remodelling acetylated chrom...
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9 |
01/01/2001 |
12836357 |
Isolation and characterization of three genes paralogous to mouse Ring3. |
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Syntenic chromosomal areas share paralogous genes which are believed to have been generated by repeated duplication of an ancestral gene. The human RING3 gene is known to have paralogous relationships...
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10 |
03/31/2000 |
10704737 |
Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9. |
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In an effort to define new cancer-testis (CT) genes, we investigated whether BRDT, a testis-restricted member of the RING3 family of transcriptional regulators, is also expressed in cancer. Standard R...
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11 |
11/01/1997 |
9367677 |
Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. |
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The RING3 gene encodes a 90-kDa mitogen-activated nuclear protein. In proliferating cells, including in leukemia, RING3 has serine-threonine kinase and autophosphorylation activities. The cloning of D...
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