| 1 |
02/01/2008 |
17342728 |
A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. |
|
| |
Many testis-specific genes from the sex chromosomes are subject to rapid evolution, which can make it difficult to identify murine genes in the human genome. The murine CYPT gene family includes 15 me...
|
| 2 |
06/01/2007 |
17373721 |
Mutational analysis of SPANX genes in families with X-linked prostate cancer. |
|
| |
BACKGROUND: Previous genetic linkage studies identified a locus for susceptibility to prostate cancer called HPCX at Xq27. The candidate region contains two clusters of SPANX genes. The first cluster ...
|
| 3 |
01/01/2007 |
17406683 |
Evolutionary diversification of SPANX-N sperm protein gene structure and expression. |
|
| |
The sperm protein associated with nucleus in the X chromosome (SPANX) genes cluster at Xq27 in two subfamilies, SPANX-A/D and SPANX-N. SPANX-A/D is specific for hominoids and is fairly well characteri...
|
| 4 |
12/15/2006 |
17036333 |
SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein. |
|
| |
SPAN-Xb is a novel cancer-testis antigen in multiple myeloma. We recently demonstrated that SPAN-Xb expression in myeloma cells is regulated through promoter methylation and could be upregulated by IL...
|
| 5 |
11/01/2006 |
17012309 |
Hominoid-specific SPANXA/D genes demonstrate differential expression in individuals and protein localization to a distinct nuclear envelope domain during spermatid morphogenesis. |
|
| |
Human sperm protein associated with the nucleus on the X chromosome consists of a five-member gene family (SPANXA1, SPANXA2, SPANXB, SPANXC and SPANXD) clustered at Xq27.1. Evolved from an ancestral S...
|
| 6 |
08/01/2006 |
17204091 |
Expression of SpanX mRNA in testicular germ cell tumors. |
|
| |
The function of SpanX proteins is unknown, evidence is accumulating to suggest their involvement in tumorigenesis. A locus in Xq27, where the SpanX gene family is located, has been associated with tes...
|
| 7 |
08/01/2006 |
16762098 |
Positive selection in the evolution of cancer. |
|
| |
We hypothesize that forms of antagonistic coevolution have forged strong links between positive selection at the molecular level and increased cancer risk. By this hypothesis, evolutionary conflict be...
|
| 8 |
04/01/2006 |
16390498 |
Expression of SpanX proteins in normal testes and in testicular germ cell tumours. |
|
| |
We investigated the expression of the SpanX protein family in cells of normal testes and in testicular germ cell tumours, mainly seminomas and embryonal carcinomas, using an immunohistochemical approa...
|
| 9 |
03/15/2006 |
16187275 |
SPAN-Xb expression in myeloma cells is dependent on promoter hypomethylation and can be upregulated pharmacologically. |
|
| |
SPAN-Xb is a novel cancer-testis antigen in multiple myeloma (MM). In this study, we determined the mechanisms regulating SPAN-Xb expression in MM. SPAN-Xb promoter sequence was first cloned into the ...
|
| 10 |
11/01/2005 |
16251457 |
Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. |
|
| |
Genetic linkage studies indicate that germline variations in a gene or genes on chromosome Xq27-28 are implicated in prostate carcinogenesis. The linkage peak of prostate cancer overlies a region of a...
|
| 11 |
06/01/2004 |
15139967 |
Expression of SPANX proteins in human-ejaculated spermatozoa and sperm precursors. |
|
| |
The sperm protein associated with nucleus in the X chromosome (SPANX) gene family is constituted by only a few members, clustered at Xq27, encoding small proteins which range from 15 to 20 kDa. These ...
|
| 12 |
03/02/2004 |
14973187 |
The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids. |
|
| |
Human sperm protein associated with the nucleus on the X chromosome (SPANX) genes comprise a gene family with five known members (SPANX-A1, -A2, -B, -C, and -D), encoding cancer/testis-specific antige...
|
| 13 |
01/01/2004 |
14734458 |
Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines. |
|
| |
PURPOSE: Members of the SPAN-X (sperm protein associated with the nucleus mapped to the X chromosome) family of cancer-testis antigens are promising targets for tumor immunotherapy because they are no...
|
| 14 |
11/01/2003 |
14595213 |
Pattern of gene expression and immune responses to Semenogelin 1 in chronic hematologic malignancies. |
|
| |
Normal testicular-specific proteins are frequently aberrantly expressed by tumor cells. Based on this, we have investigated Semenogelin 1, a major protein of human semen coagulum thought to be highly ...
|
| 15 |
05/08/2003 |
12758128 |
The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. |
|
| |
Multigenicity is one of the features of cancer/testis-associated genes. In the present study we analyzed the number and expression of genes of the SPANX(CTp11) family of cancer/testis-associated genes...
|
| 16 |
02/01/2003 |
12393489 |
Gene expression and immunologic consequence of SPAN-Xb in myeloma and other hematologic malignancies. |
|
| |
Recent studies in tumor immunology indicate that malignant cells frequently express normal testicular-specific proteins. Because these proteins show restricted normal tissue distribution, they are usu...
|
| 17 |
01/01/2001 |
11133693 |
Differential nuclear localization of the cancer/testis-associated protein, SPAN-X/CTp11, in transfected cells and in 50% of human spermatozoa. |
|
| |
Cancer-testis antigens (CTAs) represent potential targets for cancer immunotherapy because these proteins are widely distributed in tumors but not in normal tissues, except testes. In this paper, we i...
|
| 18 |
08/01/2000 |
10906052 |
Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. |
|
| |
Formation of mature spermatozoa involves a series of dramatic molecular and morphological changes in the male germ cell lineage. These changes result from the temporally regulated transcription and tr...
|
