| 1 |
12/01/2007 |
17929270 |
Inducible expression of a prostate cancer-testis antigen, SSX-2, following treatment with a DNA methylation inhibitor. |
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BACKGROUND: Active immunotherapies are one approach being developed as novel treatments for prostate cancer. Critical to the success of these therapies is the identification of appropriate target anti...
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| 2 |
09/25/2007 |
17899192 |
Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients. |
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OBJECTIVE: The purpose of this study is to identify single nucleotide polymorphisms (SNPs) in the coding region alleles of the X chromosomal LAGE-1 gene, and investigate the frequency of such SNPs in ...
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| 3 |
07/18/2007 |
17320278 |
Potential target antigens for immunotherapy in human pancreatic cancer. |
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BACKGROUND: To be effective and selective, immunotherapy ideally targets specifically tumor cells and spares normal tissues. Identification of tumor specific antigens is a prerequisite to establish an...
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| 4 |
01/15/2007 |
17154393 |
Antibody constructs in cancer therapy: protein engineering strategies to improve exposure in solid tumors. |
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Whereas over 85% of human cancers are solid tumors, of the 8 monoclonal antibodies (mAbs) currently approved for cancer therapy, 25% are directed at solid tumor surface antigens (Ags). This shortfall ...
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| 5 |
09/15/2006 |
17000678 |
Cancer-testis antigens: expression and correlation with survival in human urothelial carcinoma. |
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PURPOSE: Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. Cancer-testis antigens (CTA), a family of tumor-associated antigens,...
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| 6 |
06/15/2006 |
16751374 |
Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors. |
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Presentation of intracellular tumor-associated Ags (TAAs) in the context of HLA class I molecules offers unique cancer-specific cell surface markers for the identification and targeting of tumor cells...
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| 7 |
06/01/2006 |
16187088 |
A new LAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-A68 tumors. |
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Antigens encoded by genes of the LAGE family, including LAGE-1 and NY-ESO-1, are of interest for cancer immunotherapy because they are tumor-specific and shared by tumors of different histological typ...
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| 8 |
05/15/2006 |
16353146 |
Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer. |
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Cancer/germline (CG) antigens represent promising targets for widely applicable mono- and multiantigen cancer vaccines for nonsmall cell lung cancer (NSCLC). Since little is known about their composit...
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| 9 |
01/01/2006 |
16446548 |
A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray. |
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OBJECTIVES: To detect new specific gene expressions in squamous cell carcinoma of the esophagus. METHODS: Representational difference analysis of cDNA (cDNA RDA) was applied to a human esophageal canc...
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| 10 |
11/15/2005 |
16299236 |
Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. |
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PURPOSE: Cancer-testis genes mapping to the X chromosome have common expression patterns and show similar responses to modulators of epigenetic mechanisms. We asked whether cancer-testis gene expressi...
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| 11 |
09/01/2005 |
16438850 |
[The expression of 11 cancer/testis (CT) antigen genes in esophageal carcinoma] |
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OBJECTIVE: To investigate the expression status of 11 different cancer/testis (CT) antigen genes in esophageal carcinoma. METHODS: Esophageal carcinoma tissue and adjacent normal esophageal mucosa tak...
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| 12 |
04/01/2005 |
16091172 |
[Expression of NY-ESO-1 and LAGE-1 cancer-testis antigens in hepatocellular carcinoma] |
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OBJECTIVE: To study the role of NY-ESO-1 and LAGE-1 cancer-testis antigens as targets for immunotherapy and the relationship between corresponding gene expression and biologic behavior of hepatocellul...
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| 13 |
03/01/2005 |
15756003 |
Expression profile of cancer-testis genes in 121 human colorectal cancer tissue and adjacent normal tissue. |
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PURPOSE: Among tumor antigens identified to date, cancer-testis (CT) antigens, which are coded by CT genes, are identified as a group of highly attractive targets for cancer vaccines. This study is th...
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| 14 |
02/01/2005 |
15661935 |
Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma. |
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Immunotherapy is being proposed to treat patients with hepatocellular carcinoma (HCC). However, more detailed knowledge on tumor Ag expression and specific immune cells is required for the preparation...
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| 15 |
01/01/2005 |
16255778 |
Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells. |
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BACKGROUND: The retinoic acid receptor beta 2 (RARbeta2) gene modulates proliferation and survival of cultured human breast cancer cells. Previously we showed that ectopic expression of RARbeta2 in a ...
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| 16 |
12/15/2004 |
15623618 |
Immunohistochemical and molecular analysis of human melanomas for expression of the human cancer-testis antigens NY-ESO-1 and LAGE-1. |
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PURPOSE: NY-ESO-1 and LAGE-1 are homologous cancer-testis antigens, which are expressed in many different cancers. It is essential to type tumors accurately to assess patient suitability for clinical ...
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| 17 |
12/02/2004 |
15730810 |
[Expression of NY-ESO-1/LAGE-1 genes in hepatocellular carcinoma and autologous humoral responses induced thereby] |
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OBJECTIVE: To investigate the potential of utilizing NY-ESO-1/LAGE-1 antigens in hepatocellular carcinoma (HCC) vaccines. METHODS: RT-PCR method was used to detect the expression of NY-ESO-1/LAGE-1 mR...
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| 18 |
11/01/2004 |
15516106 |
Cancer/testis antigen expression and autologous humoral immunity to NY-ESO-1 in gastric cancer. |
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Gastric cancer has the highest mortality rate and the second-highest morbidity rate of all malignant tumors in China. Since cancer/testis (CT) antigens are expressed in various types of human tumors b...
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| 19 |
08/01/2004 |
15459874 |
[Adaptive immunotherapy of the advanced prostate cancer - cancer testis antigen (CTA) as possible target antigens] |
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Prostate cancer (PCa) like other tumors expresses antigens that may serve as target for specific immunotherapy. Special antigen-presenting cells (e. g., dendritic cells) are capable of generating tumo...
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| 20 |
05/01/2004 |
14747957 |
Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display. |
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Serological cloning of tumor-associated antigens (TAAs) using patient autoantibodies and tumor cDNA expression libraries (SEREX) has identified a wide array of tumor proteins eliciting B-cell response...
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